Reaction profile

The FDA adverse-event record for central nervous system depression

55 FDA adverse-event reports reference central nervous system depression (VeDDRA 628). See the species, breeds, and drugs most associated with it below.

55
reports citing this reaction
43.6%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
55
Total Reports
24
Deaths
43.6%
Death Rate

Species Most Affected

Dog 26
Cat 8
Horse 7
Chicken 5
Human 4
Other 3
Sheep 1
Alpaca 1

Breeds Most Affected

Unknown 8
Domestic Shorthair 5
Chicken (other) 5
Quarter Horse 3
Dog (other) 2
Boxer (German Boxer) 2
Retriever - Labrador 2
Cat (unknown) 2
Beagle 2
American Pit Bull Terrier 2

Associated Drugs

Moxidectin 6
Milbemycin Oxime + Spinosad 4
Prednisone 4
Doxycycline 4
Ivermectin 3
Trilostane 3
Ceftiofur Crystalline Free Acid 3
Carprofen 3
Narasin + Nicarbazin 3
Intralipid Therapy 3
Cyclosporine A 2
Deracoxib 2
Fluralaner Chew Tablets 2
Ivermectin + Pyrantel 2
Gabapentin 2
Zoalene (3.5-Dinitro-O-Toluamide) 2
Frunevetmab 2
Verdinexor 2
Ivermectin(1%)/Clorsulon(10%) Injection 1
Desoxycorticosterone Pivalate 1

Central nervous system depression Reaction Insights

55 reports name Central nervous system depression; 24 recorded a death outcome (43.6% of reported events, not a population-level mortality rate). VeDDRA code: 628.

By species: Dog (26 reports), Cat (8 reports), Horse (7 reports). By breed: Unknown (8), Domestic Shorthair (5), Chicken (other) (5).

Most co-reported drugs: Moxidectin (6 reports), Milbemycin Oxime + Spinosad (4 reports), Prednisone (4 reports), Doxycycline (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.