Reaction profile

The FDA adverse-event record for injection site pruritus

205 FDA adverse-event reports reference injection site pruritus (VeDDRA 97). See the species, breeds, and drugs most associated with it below.

205
reports citing this reaction
2.0%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
205
Total Reports
4
Deaths
2.0%
Death Rate

Species Most Affected

Dog 122
Cat 52
Human 13
Horse 10
Cattle 3
Rabbit 2
Mouse 1
Other Equids 1
Bat 1

Breeds Most Affected

Domestic Shorthair 25
Unknown 15
Domestic (unspecified) 13
Crossbred Canine/dog 10
Retriever - Golden 10
Retriever - Labrador 10
Beagle 7
Dog (unknown) 6
Chihuahua 6
Shepherd Dog - German 5

Associated Drugs

Moxidectin 42
Cefovecin 19
Carprofen 16
Frunevetmab 16
Bedinvetmab 14
Ceftiofur Crystalline Free Acid 10
Enrofloxacin 9
Meloxicam 9
Melarsomine Dihydrochloride Injection 9
Cefovecin Sodium 8
Praziquantel 8
Melarsomine Dihydrochloride 8
Diphenhydramine Hcl 7
Gabapentin 6
Selamectin 5
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 5
Prednisone 5
Maropitant Citrate 5
Oclacitinib Maleate 5
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 5

Injection site pruritus Reaction Insights

205 reports name Injection site pruritus; 4 recorded a death outcome (2.0% of reported events, not a population-level mortality rate). VeDDRA code: 97.

By species: Dog (122 reports), Cat (52 reports), Human (13 reports). By breed: Domestic Shorthair (25), Unknown (15), Domestic (unspecified) (13).

Most co-reported drugs: Moxidectin (42 reports), Cefovecin (19 reports), Carprofen (16 reports), Frunevetmab (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.