Reaction profile

The FDA adverse-event record for dry skin

1,059 FDA adverse-event reports reference dry skin (VeDDRA 1998). See the species, breeds, and drugs most associated with it below.

1,059
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
1,059
Total Reports
23
Deaths
2.2%
Death Rate

Species Most Affected

Dog 941
Cat 72
Human 28
Cattle 8
Horse 8
Raccoon 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 132
Crossbred Canine/dog 68
Chihuahua 55
Terrier - Yorkshire 41
Retriever - Golden 39
Dog (unknown) 37
Shepherd Dog - German 36
Shih Tzu 33
Domestic Shorthair 30
Unknown 29

Associated Drugs

Afoxolaner 345
Milbemycin Oxime + Spinosad 119
Ivermectin + Pyrantel As Pamoate Salt 81
Spinosad 65
Selamectin 62
Trilostane 54
Imidacloprid + Moxidectin 52
Fluralaner Chew Tablets 44
Oclacitinib Maleate 30
Carprofen 25
Nitenpyram 20
Prednisone 19
Fluralaner 13.64% 12-Week Chew 17
Flumethrin-Imidacloprid 16
Maropitant Citrate 15
Gabapentin 15
Bedinvetmab 15
Cyclosporine 13
Moxidectin 13
Milbemycin Oxime + Praziquantel 12

Dry skin Reaction Insights

1,059 reports name Dry skin; 23 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). VeDDRA code: 1998.

By species: Dog (941 reports), Cat (72 reports), Human (28 reports). By breed: Retriever - Labrador (132), Crossbred Canine/dog (68), Chihuahua (55).

Most co-reported drugs: Afoxolaner (345 reports), Milbemycin Oxime + Spinosad (119 reports), Ivermectin + Pyrantel As Pamoate Salt (81 reports), Spinosad (65 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.