Reaction profile

The FDA adverse-event record for dehydration

7,651 FDA reports name dehydration, a high-volume reaction in the CVM extract (VeDDRA 1208). Plate stamps and neighbourhood peers follow.

#62 of 2,481
by report volume (all reactions)
7,651
reports citing this reaction
26.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dehydration has 7,651 reports now versus 7,501 in that prior snapshot: 150 more (2.0%).

Report change
+150
Death-coded reports
+31
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dehydration changes

FDA AER · VeDDRA plate

Code 1208 VOL-HIGH

VOL-HIGH · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 7,651 reports
  • DEATH-HOT 26.5%
  • TOP-DECILE #62/2481
  • PHOTO-FINISH Polyuria
  • SPECIES-DOG Dog · 5,202
  • DRUG-LEAD Maropitant Citrate · 814
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Polyuria (±96 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Dehydration

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Drooling · near7886Polyuria · near7747Dehydration · this reaction7651Elevated creatinine · near7526Hyperactivity · near7434Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Dehydration

Dehydration: high death-coded share in the FDA AER plate

Signature read: 2,025 death-coded reports is a heavy tail count for Dehydration in the CVM extract. Report volume is upper-third scale: 7,651 named reports in the openFDA extract. Death-coded share is upper-third: 2,025 of 7,651 reports (26.5% of named reports). Nearest volume peer: Polyuria (±96 reports). Lead species Dog (5,202). Lead co-reported drug Maropitant Citrate (814).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 5,202
Cat 2,258
Horse 79
Cattle 38
Chicken 17
Human 16
Turkey 11
Pig 4
Ferret 3
Goat 3

Breeds Most Affected

Domestic Shorthair 1,379
Retriever - Labrador 577
Crossbred Canine/dog 385
Chihuahua 287
Terrier - Yorkshire 234
Retriever - Golden 204
Domestic (unspecified) 192
Shih Tzu 181
Domestic Longhair 148
Dachshund (unspecified) 145

Associated Drugs

Maropitant Citrate 814
Milbemycin Oxime + Spinosad 654
Carprofen 642
Spinosad 348
Meloxicam 342
Cefovecin 332
Moxidectin 303
Gabapentin 301
Buprenorphine 277
Deracoxib 259
Trilostane 243
Afoxolaner 235
Bexagliflozin 229
Fluralaner Chew Tablets 224
Famotidine 209
Selamectin 208
Prednisone 200
Pyrantel Pamoate;Sarolaner 198
Metronidazole 186
Bedinvetmab 185

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Dehydration, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (7,651 here).

Similar death-coded share

Nearest other reactions by death-coded share (26.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dehydration (#62 of 2,481 by report volume); death-coded 26.5%. PlainBreed reaction plate · death-coded report count stamp 2,025 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →