Reaction profile

The FDA adverse-event record for defect unknown/not specified

1,194 FDA adverse-event reports reference defect unknown/not specified (VeDDRA 99009). See the species, breeds, and drugs most associated with it below.

1,194
reports citing this reaction
2.6%
death-coded share
Unknown
most-affected species
Meloxicam
most-associated drug
Verify with FDA CVM →
1,194
Total Reports
31
Deaths
2.6%
Death Rate

Species Most Affected

Unknown 825
Dog 267
Cat 79
Human 12
Horse 5
Goat 2
Cattle 2
Other 1
Sheep 1

Breeds Most Affected

Unknown 840
Dog (unknown) 41
Domestic Shorthair 30
Cat (unknown) 23
Retriever - Labrador 22
Crossbred Canine/dog 21
Retriever - Golden 13
Shepherd Dog - German 12
Chihuahua 10
Shih Tzu 9

Associated Drugs

Meloxicam 149
Fenbendazol Granules 133
Cyclosporin Ointment 126
Insulin Injectable Vial 62
Milbemycin Oxime + Spinosad 55
Fluralaner Spot-On Solution 53
Milbemycin Oxime + Praziquantel 42
Fluralaner Chew Tablets 39
Enrofloxacin 36
Oxytetracycline Dihydrate 34
Orbifloxacin Oral Suspension 31
Carprofen 30
Lotilaner 29
Cyclosporine 26
Imidacloprid + Moxidectin 25
Spinosad 20
Genta/Momet/Clotrim Ear Oint 20
Buprenorphine 20
Febantel + Praziquantel + Pyrantel Pamoate 19
Vetpen Starter Kit 18

Defect Unknown/Not Specified Reaction Insights

1,194 reports name Defect Unknown/Not Specified; 31 recorded a death outcome (2.6% of reported events, not a population-level mortality rate). VeDDRA code: 99009.

By species: Unknown (825 reports), Dog (267 reports), Cat (79 reports). By breed: Unknown (840), Dog (unknown) (41), Domestic Shorthair (30).

Most co-reported drugs: Meloxicam (149 reports), Fenbendazol Granules (133 reports), Cyclosporin Ointment (126 reports), Insulin Injectable Vial (62 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.