Reaction profile

The FDA adverse-event record for application site serous discharge

90 FDA adverse-event reports reference application site serous discharge (VeDDRA 34). See the species, breeds, and drugs most associated with it below.

90
reports citing this reaction
1.1%
death-coded share
Cat
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
90
Total Reports
1
Deaths
1.1%
Death Rate

Species Most Affected

Cat 58
Dog 20
Unknown 8
Horse 2
Cattle 1
Human 1

Breeds Most Affected

Domestic Shorthair 35
Unknown 9
Pit Bull 7
Siamese 5
Maine Coon 4
Domestic Longhair 4
Dog (unknown) 2
Crossbred Canine/dog 2
Sphynx 2
Shepherd Dog - German 1

Associated Drugs

Imidacloprid + Moxidectin 23
Selamectin 20
Device: Suture 9
Selamectin;Sarolaner 7
Flumethrin-Imidacloprid 6
Bupivacaine Lipsome Injectable Suspension 5
Rabies Vaccine 4
Emodepside + Praziquantel 4
Buprenorphine 4
Diphenhydramine 3
Hydromorphone 3
Carprofen 3
Cefovecin Sodium 3
Fluralaner/Moxidectin Spot-On 3
Cefovecin 3
Feline Leukemia Vaccine 2
Amoxicillin 2
Metronidazole 2
Midazolam 2
Propofol 2

Application site serous discharge Reaction Insights

90 reports name Application site serous discharge; 1 recorded a death outcome (1.1% of reported events, not a population-level mortality rate). VeDDRA code: 34.

By species: Cat (58 reports), Dog (20 reports), Unknown (8 reports). By breed: Domestic Shorthair (35), Unknown (9), Pit Bull (7).

Most co-reported drugs: Imidacloprid + Moxidectin (23 reports), Selamectin (20 reports), Device: Suture (9 reports), Selamectin;Sarolaner (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.