Reaction profile

The FDA adverse-event record for scratching

6,922 FDA adverse-event reports reference scratching (VeDDRA 959). See the species, breeds, and drugs most associated with it below.

6,922
reports citing this reaction
1.0%
death-coded share
Dog
most-affected species
Nitenpyram
most-associated drug
Verify with FDA CVM →
6,922
Total Reports
71
Deaths
1.0%
Death Rate

Species Most Affected

Dog 4,942
Cat 1,766
Cattle 205
Unknown 2
Horse 2
Human 2
Goat 1
Donkey 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 963
Crossbred Canine/dog 375
Retriever - Labrador 367
Dog (unknown) 322
Chihuahua 315
Shih Tzu 246
Terrier - Yorkshire 239
Shepherd Dog - German 228
Domestic Longhair 212
Retriever - Golden 160

Associated Drugs

Nitenpyram 1,122
Afoxolaner 912
Milbemycin Oxime + Spinosad 870
Spinosad 625
Fluralaner Chew Tablets 422
Ivermectin + Pyrantel As Pamoate Salt 245
Selamectin 229
Frunevetmab 210
Lotilaner 186
Fluralaner Spot-On Solution 181
Fluralaner 13.64% 12-Week Chew 163
Pyrantel Pamoate;Sarolaner 138
Imidacloprid + Moxidectin 133
Selamectin;Sarolaner 110
Moxidectin 92
Ivermectin 0.5% Pour-On Topical Solution 85
Milbemycin Oxime + Praziquantel 85
Oclacitinib Maleate 84
Portech App Gun 65 Ml Ivomec/Eprinex 78
Sarolaner 76

Scratching Reaction Insights

6,922 reports name Scratching; 71 recorded a death outcome (1.0% of reported events, not a population-level mortality rate). VeDDRA code: 959.

By species: Dog (4,942 reports), Cat (1,766 reports), Cattle (205 reports). By breed: Domestic Shorthair (963), Crossbred Canine/dog (375), Retriever - Labrador (367).

Most co-reported drugs: Nitenpyram (1,122 reports), Afoxolaner (912 reports), Milbemycin Oxime + Spinosad (870 reports), Spinosad (625 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.