Reaction profile

The FDA adverse-event record for low blood urea nitrogen (bun)

549 FDA reports name low blood urea nitrogen (bun), a high-volume reaction in the CVM extract (VeDDRA 2700). Plate stamps and neighbourhood peers follow.

#610 of 2,481
by report volume (all reactions)
549
reports citing this reaction
24.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Low blood urea nitrogen (BUN) has 549 reports now versus 530 in that prior snapshot: 19 more (3.6%).

Report change
+19
Death-coded reports
+2
Death-coded share
−0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Low blood urea nitrogen (BUN) changes

FDA AER · VeDDRA plate

Code 2700 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 549 reports
  • DEATH-HOT 24.0%
  • UPPER-Q #610/2481
  • PHOTO-FINISH Fly biting behaviour
  • SPECIES-DOG Dog · 378
  • DRUG-LEAD Maropitant Citrate · 71
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Fly biting behaviour (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Low blood urea nitrogen

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Fly biting behaviour · near550Increased borborygmus · near550Pallor · near550Low blood urea nitrog… · thi…549Horner's syndrome · near548Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Low blood urea nitrogen (BUN)

What the FDA AER plate says about Low blood urea nitrogen (BUN)

Signature read: 132 death-coded reports is a heavy tail count for Low blood urea nitrogen (BUN) in the CVM extract. Report volume is upper-third scale: 549 named reports in the openFDA extract. 132 of 549 reports were death-coded (24.0% of named reports, not a population mortality rate). Nearest volume peer: Fly biting behaviour (±1 reports). Lead species Dog (378). Lead co-reported drug Maropitant Citrate (71).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Maropitant Citrate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 378
Cat 167
Rabbit 1
Cattle 1
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 99
Retriever - Labrador 57
Crossbred Canine/dog 33
Retriever - Golden 22
Shih Tzu 14
Domestic (unspecified) 12
Chihuahua 12
Domestic Mediumhair 12
Pug 11
Terrier - Yorkshire 11

Associated Drugs

Maropitant Citrate 71
Carprofen 68
Trilostane 34
Afoxolaner 32
Buprenorphine 32
Cefovecin 27
Meloxicam 25
Milbemycin Oxime + Spinosad 23
Robenacoxib 22
Enrofloxacin 22
Maropitant 20
Metronidazole 20
Oclacitinib Maleate 19
Cefovecin Sodium 18
Propofol 18
Famotidine 17
Isoflurane 17
Fluralaner Chew Tablets 17
Fluid Therapy 17
Eprinomectin + Esafoxolaner + Praziquantel 16

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Low blood urea nitrogen (BUN), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (549 here).

Similar death-coded share

Nearest other reactions by death-coded share (24.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Low blood urea nitrogen (BUN) (#610 of 2,481 by report volume); death-coded 24.0%. PlainBreed reaction plate · death-coded report count stamp 132 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →