Reaction profile

The FDA adverse-event record for low blood urea nitrogen (bun)

497 FDA adverse-event reports reference low blood urea nitrogen (bun) (VeDDRA 2700). See the species, breeds, and drugs most associated with it below.

497
reports citing this reaction
24.5%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
497
Total Reports
122
Deaths
24.5%
Death Rate

Species Most Affected

Dog 355
Cat 138
Rabbit 1
Cattle 1
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 79
Retriever - Labrador 53
Crossbred Canine/dog 33
Retriever - Golden 20
Shih Tzu 14
Domestic (unspecified) 12
Chihuahua 12
Terrier - Yorkshire 11
Dachshund (unspecified) 10
Domestic Mediumhair 10

Associated Drugs

Carprofen 66
Maropitant Citrate 52
Trilostane 33
Afoxolaner 28
Cefovecin 24
Buprenorphine 24
Milbemycin Oxime + Spinosad 23
Meloxicam 22
Maropitant 20
Metronidazole 18
Enrofloxacin 18
Famotidine 17
Oclacitinib Maleate 17
Fluralaner Chew Tablets 17
Robenacoxib 16
Propofol 14
Spinosad 13
Isoflurane 13
Cefovecin Sodium 12
Selamectin 12

Low blood urea nitrogen (BUN) Reaction Insights

497 reports name Low blood urea nitrogen (BUN); 122 recorded a death outcome (24.5% of reported events, not a population-level mortality rate). VeDDRA code: 2700.

By species: Dog (355 reports), Cat (138 reports), Rabbit (1 reports). By breed: Domestic Shorthair (79), Retriever - Labrador (53), Crossbred Canine/dog (33).

Most co-reported drugs: Carprofen (66 reports), Maropitant Citrate (52 reports), Trilostane (33 reports), Afoxolaner (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.