Drug profile

The FDA adverse-event record for Velagliflozin

54 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Velagliflozin. Species, reactions, and outcomes follow.

#1075 of 2,679
by report volume (all drugs)
54
adverse-event reports
14.8%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Velagliflozin ranks #1065 of 2679 by total reports (54) and #370 of 1130 by death-coded share (14.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1065
This drug, reports of 2679
#370
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Velagliflozin has 54 reports now versus 51 in that prior snapshot: 3 more (5.9%).

Report change
+3
Death-coded reports
+1
Death-coded share
+1.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Velagliflozin changes

Signature read: death-coded report count at 8 is the most distinctive stamp on Velagliflozin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
54
Total Reports
8
Deaths Reported
14.8%
Death-coded share of reports

Active Ingredients

Velagliflozin

Administration Routes

UnknownOral

Species Affected

Cat 51
Unknown 3

Most Affected Breeds

Domestic Shorthair 35
Cat (unknown) 5
Domestic Longhair 5
Unknown 3
Russian 1
Siamese 1
Domestic Mediumhair 1
Turkish Van 1
Crossbred Feline/cat 1
Persian 1

Most Reported Reactions

Ketosis 13
Diarrhoea 13
Lack of efficacy - NOS 12
Weight loss 10
Vomiting 8
Hyperglycaemia 8
Death by euthanasia 8
Glucosuria 8
Elevated symmetrical dimethylarginine (SDMA) 7
Elevated creatinine 6
Elevated blood urea nitrogen (BUN) 5
Other abnormal test result NOS 4

Outcome Breakdown

Outcome Unknown
23 (45.1%)
Ongoing
15 (29.4%)
Euthanized
8 (15.7%)
Recovered/Normal
5 (9.8%)

Velagliflozin Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Velagliflozin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (14.8% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Velagliflozin (#1075 of 2,679 by report volume); death-coded 14.8%. PlainBreed drug row · death-coded report count stamp 8 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →