Drug profile

The FDA adverse-event record for Cosequin

235 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cosequin. See the species affected, top reactions, and outcomes below.

235
adverse-event reports
14.9%
death-coded share
Dog
most-reported species
25
Death by euthanasia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
235
Total Reports
35
Deaths Reported
14.9%
Death Rate

Active Ingredients

Cosequin

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 184
Cat 51

Most Affected Breeds

Domestic Shorthair 38
Retriever - Labrador 37
Shepherd Dog - German 16
Retriever - Golden 15
Boxer (German Boxer) 9
Shepherd Dog - Australian 8
Crossbred Canine/dog 7
Terrier - Yorkshire 5
Terrier - Bull - American Pit 5
Collie - Border 5

Most Reported Reactions

Death by euthanasia 25
Lethargy (see also Central nervous system depression in Neurological) 24
Vomiting 23
Seizure NOS 21
Ataxia 20
Diarrhoea 18
Panting 17
Polydipsia 17
Lack of efficacy - NOS 15
Elevated alanine aminotransferase (ALT) 15
Weight loss 13
Not eating 13

Outcome Breakdown

Ongoing
134 (57.0%)
Recovered/Normal
37 (15.7%)
Outcome Unknown
29 (12.3%)
Euthanized
26 (11.1%)
Died
9 (3.8%)

Cosequin Adverse Event Insights

235 reports name Cosequin; 35 recorded a death outcome (14.9% of reported events, not a population-level mortality rate). Active ingredient: Cosequin. Administration routes: Oral, Unknown, Subcutaneous.

By species: Dog (184 reports), Cat (51 reports). By breed: Domestic Shorthair (38), Retriever - Labrador (37), Shepherd Dog - German (16).

Leading clinical signs: Death by euthanasia (25), Lethargy (see also Central nervous system depression in Neurological) (24), Vomiting (23), Seizure NOS (21). Outcome, 235 coded reports: Ongoing leads at 57.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.