Drug profile

The FDA adverse-event record for Steroid (Unknown)

441 FDA reports name Steroid (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#333 of 2,679
by report volume (all drugs)
441
adverse-event reports
9.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Steroid (Unknown) ranks #332 of 2679 by total reports (441) and #579 of 1130 by death-coded share (9.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#332
This drug, reports of 2679
#579
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Steroid (Unknown) has 441 reports now versus 433 in that prior snapshot: 8 more (1.8%).

Report change
+8
Death-coded reports
+1
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Steroid (Unknown) changes

Signature read: 441 reports place Steroid (Unknown) in the upper third of FDA AER volume (#333 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
441
Total Reports
41
Deaths Reported
9.3%
Death-coded share of reports

Active Ingredients

Steroid (Unknown)

Administration Routes

UnknownOralParenteralSubcutaneousTopicalRespiratory (Inhalation)Auricular (Otic)OphthalmicIntraocularIntra-Articular

Species Affected

Dog 315
Cat 122
Human 3
Cattle 1

Most Affected Breeds

Domestic Shorthair 62
Retriever - Labrador 18
Dog (unknown) 18
Chihuahua 17
Shepherd Dog - German 17
Terrier - Yorkshire 16
Cat (unknown) 15
Pit Bull 15
Domestic Longhair 13
Beagle 12

Most Reported Reactions

Vomiting 72
Emesis 68
Lack of efficacy - NOS 54
Lethargy (see also Central nervous system depression in 'Neurological') 41
Diarrhoea 39
Lack of efficacy (ectoparasite) - flea 36
Weight loss 30
Not eating 27
Behavioural disorder NOS 25
Seizure NOS 22
Death by euthanasia 21
Other abnormal test result NOS 21

Outcome Breakdown

Outcome Unknown
152 (34.5%)
Recovered/Normal
121 (27.4%)
Ongoing
103 (23.4%)
Recovered with Sequela
24 (5.4%)
Euthanized
21 (4.8%)
Died
20 (4.5%)

Steroid (Unknown): high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Steroid (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Steroid (Unknown) (#333 of 2,679 by report volume); death-coded 9.3%. PlainBreed drug row · report volume stamp 441 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →