Drug profile

The FDA adverse-event record for Unknown If Concomitant Medications

86 FDA reports name Unknown If Concomitant Medications, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#850 of 2,679
by report volume (all drugs)
86
adverse-event reports
9.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Unknown If Concomitant Medications ranks #843 of 2679 by total reports (86) and #578 of 1130 by death-coded share (9.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#843
This drug, reports of 2679
#578
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Unknown If Concomitant Medications has 86 reports now versus 86 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Unknown If Concomitant Medications changes

Signature read: 86 reports place Unknown If Concomitant Medications in the upper third of FDA AER volume (#850 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
86
Total Reports
8
Deaths Reported
9.3%
Death-coded share of reports

Active Ingredients

Unknown If Concomitant Medications

Administration Routes

Unknown

Species Affected

Dog 61
Cat 23
Human 2

Most Affected Breeds

Cat (unknown) 18
Dog (unknown) 15
Crossbred Canine/dog 5
Unknown 3
Terrier - Yorkshire 3
Pit Bull 3
Boxer (German Boxer) 3
Bichon Frise 2
Terrier (unspecified) 2
Schnauzer (unspecified) 2

Most Reported Reactions

Emesis 18
Diarrhoea 10
Hyperactivity 6
Lethargy (see also Central nervous system depression in 'Neurological') 5
Vomiting 5
Lack of efficacy - NOS 5
Anorexia 4
Death by euthanasia 4
Systemic disorder NOS 4
Other abnormal test result NOS 3
Skin lesion NOS 3
Emesis (multiple) 3

Outcome Breakdown

Outcome Unknown
33 (38.4%)
Recovered/Normal
33 (38.4%)
Ongoing
12 (14.0%)
Euthanized
5 (5.8%)
Died
3 (3.5%)

Unknown If Concomitant Medications: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Unknown If Concomitant Medications, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (86 here).

What to do with this drug

  • Compare Unknown If Concomitant Medications's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Unknown If Concomitant Medications (#850 of 2,679 by report volume); death-coded 9.3%. PlainBreed drug row · report volume stamp 86 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →