Drug profile

The FDA adverse-event record for Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract

440 FDA reports name Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#334 of 2,679
by report volume (all drugs)
440
adverse-event reports
10.5%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract ranks #334 of 2679 by total reports (440) and #527 of 1130 by death-coded share (10.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#334
This drug, reports of 2679
#527
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract has 440 reports now versus 429 in that prior snapshot: 11 more (2.6%).

Report change
+11
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract changes

Signature read: 440 reports place Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract in the upper third of FDA AER volume (#334 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
440
Total Reports
46
Deaths Reported
10.5%
Death-coded share of reports

Active Ingredients

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract

Administration Routes

SubcutaneousParenteralUnknownOralSubconjunctivalOther

Species Affected

Dog 440

Most Affected Breeds

Retriever - Labrador 47
Shepherd Dog - Australian 34
Retriever - Golden 32
Chihuahua 24
Pit Bull 23
Shih Tzu 18
Dachshund (unspecified) 17
Shepherd Dog - German 16
Crossbred Canine/dog 12
Bulldog - French 10

Most Reported Reactions

Vomiting 121
Other abnormal test result NOS 71
Diarrhoea 58
Lethargy (see also Central nervous system depression in Neurological) 54
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 41
Lethargy (see also Central nervous system depression in 'Neurological') 40
Anaphylaxis 36
Not eating 31
Death 28
Pale mucous membrane 26
Facial swelling (see also 'Skin') 25
Leucocytosis NOS 24

Outcome Breakdown

Outcome Unknown
155 (35.1%)
Recovered/Normal
148 (33.6%)
Ongoing
90 (20.4%)
Died
29 (6.6%)
Euthanized
17 (3.9%)
Recovered with Sequela
2 (0.5%)

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (440 here).

Food 441 Steroid (Unknown) 441 Genta/Posacon/Mometa Eardrops 438 Vaccine 442

Similar death-coded share

Nearest other drugs by death-coded share (10.5% here), distinct from the volume row.

Gentamicin Sulfate & Betamethasone Valerate 10.4% Gentamicin Sulfate, Betamethasone Valerate & Clotrimazole 10.4% Chlorpheniramine 10.5% Frunevetmab 10.4%

What to do with this drug

  • Compare Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (#334 of 2,679 by report volume); death-coded 10.5%. PlainBreed drug row · report volume stamp 440 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →