Drug profile

The FDA adverse-event record for Shampoo

532 FDA reports name Shampoo, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#290 of 2,679
by report volume (all drugs)
532
adverse-event reports
5.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Shampoo ranks #290 of 2679 by total reports (532) and #791 of 1130 by death-coded share (5.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#290
This drug, reports of 2679
#791
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Shampoo has 532 reports now versus 531 in that prior snapshot: 1 more (0.2%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Shampoo changes

Signature read: 532 reports place Shampoo in the upper third of FDA AER volume (#290 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
532
Total Reports
27
Deaths Reported
5.1%
Death-coded share of reports

Active Ingredients

Shampoo

Administration Routes

TopicalUnknownCutaneous

Species Affected

Dog 453
Cat 73
Human 2
Ferret 1
Rabbit 1
Cattle 1
Goat 1

Most Affected Breeds

Chihuahua 37
Domestic Shorthair 31
Shih Tzu 30
Terrier - Yorkshire 29
Crossbred Canine/dog 28
Dog (unknown) 23
Maltese 20
Retriever - Labrador 16
Shepherd Dog - German 14
Cat (unknown) 13

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 226
Pruritus 121
Lethargy (see also Central nervous system depression in 'Neurological') 50
Behavioural disorder NOS 41
Vomiting 40
Diarrhoea 29
Anorexia 27
Lethargy (see also Central nervous system depression in Neurological) 25
Weight loss 24
Application site pruritus 23
Ataxia 22
Scratching 22

Outcome Breakdown

Outcome Unknown
301 (56.6%)
Ongoing
112 (21.1%)
Recovered/Normal
87 (16.4%)
Died
14 (2.6%)
Euthanized
13 (2.4%)
Recovered with Sequela
5 (0.9%)

Shampoo: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Shampoo, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (5.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Shampoo (#290 of 2,679 by report volume); death-coded 5.1%. PlainBreed drug row · report volume stamp 532 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →