Drug profile

The FDA adverse-event record for Medetomidine Hydrochloride, Vatinoxan Hydrochloride

489 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Medetomidine Hydrochloride, Vatinoxan Hydrochloride. See the species affected, top reactions, and outcomes below.

489
adverse-event reports
6.7%
death-coded share
Dog
most-reported species
251
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
489
Total Reports
33
Deaths Reported
6.7%
Death Rate

Active Ingredients

Medetomidine Hydrochloride, Vatinoxan Hydrochloride

Administration Routes

IntramuscularUnknownIntravenousSubcutaneous

Species Affected

Dog 480
Unknown 3
Cat 3
Human 2
Bobcat 1

Most Affected Breeds

Dog (unknown) 200
Retriever - Labrador 47
American Pit Bull Terrier 26
Shepherd Dog - German 18
Retriever - Golden 13
Dog (other) 11
Boxer (German Boxer) 10
Chihuahua 10
Shepherd Dog - Australian 10
Rottweiler 8

Most Reported Reactions

Lack of efficacy - NOS 251
Diarrhoea 45
Sedation prolonged 35
Bradycardia 25
Partial lack of efficacy 21
Tachycardia 19
Hypotension 16
Vomiting 16
Death 16
Involuntary defecation 15
Unrelated death 13
Immediate pain upon injection 12

Outcome Breakdown

Recovered/Normal
401 (81.8%)
Outcome Unknown
53 (10.8%)
Died
18 (3.7%)
Euthanized
15 (3.1%)
Ongoing
3 (0.6%)

Medetomidine Hydrochloride, Vatinoxan Hydrochloride Adverse Event Insights

489 reports name Medetomidine Hydrochloride, Vatinoxan Hydrochloride; 33 recorded a death outcome (6.7% of reported events, not a population-level mortality rate). Active ingredient: Medetomidine Hydrochloride, Vatinoxan Hydrochloride. Administration routes: Intramuscular, Unknown, Intravenous, Subcutaneous.

By species: Dog (480 reports), Unknown (3 reports), Cat (3 reports). By breed: Dog (unknown) (200), Retriever - Labrador (47), American Pit Bull Terrier (26).

Leading clinical signs: Lack of efficacy - NOS (251), Diarrhoea (45), Sedation prolonged (35), Bradycardia (25). Outcome, 490 coded reports: Recovered/Normal leads at 81.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.