Protamine Zinc Recombinant Human Insulin
1,762 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,762
Total Reports
81
Deaths Reported
460.0%
Death Rate
Active Ingredients
Protamine Zinc Recombinant Human Insulin
Administration Routes
UnknownSubcutaneousParenteralOralIntramuscularSubconjunctival
Species Affected
Cat 783
Unknown 757
Dog 215
Human 7
Most Affected Breeds
Unknown 764
Domestic Shorthair 448
Cat (unknown) 157
Domestic Longhair 67
Domestic Mediumhair 29
Siamese 22
Dog (unknown) 18
Retriever - Labrador 18
Terrier - Yorkshire 16
Maine Coon 15
Most Reported Reactions
Containers, Damaged 388
INEFFECTIVE, GLYCEMIC CONTROL 377
Lack of efficacy - NOS 296
Vials, Damaged 231
Hypoglycaemia 165
Appearance, Abnormal 79
Vomiting 68
Product Defect, General 67
INEFFECTIVE, LOSS OF EFFECT 66
Death by euthanasia 60
Seal, Abnormal 47
Lethargy (see also Central nervous system depression in 'Neurological') 45
Outcome Breakdown
Outcome Unknown
707 (70.2%)
Recovered/Normal
172 (17.1%)
Euthanized
60 (6.0%)
Ongoing
47 (4.7%)
Died
21 (2.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.