Drug profile

The FDA adverse-event record for Prescription Diet

482 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Prescription Diet. See the species affected, top reactions, and outcomes below.

482
adverse-event reports
12.7%
death-coded share
Cat
most-reported species
100
Weight loss - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
482
Total Reports
61
Deaths Reported
12.7%
Death Rate

Active Ingredients

Prescription Diet

Administration Routes

UnknownOral

Species Affected

Cat 265
Dog 216
Fallow 1

Most Affected Breeds

Domestic Shorthair 175
Domestic Longhair 34
Retriever - Labrador 21
Cat (unknown) 17
Domestic Mediumhair 13
Retriever - Golden 12
Chihuahua 11
Crossbred Canine/dog 10
Terrier - Yorkshire 9
Shih Tzu 8

Most Reported Reactions

Weight loss 100
Ketosis 96
Diarrhoea 94
Vomiting 83
Lack of efficacy - NOS 65
Hyperglycaemia 65
Lethargy (see also Central nervous system depression in Neurological) 57
Not eating 48
Death by euthanasia 43
Other abnormal test result NOS 42
Elevated alanine aminotransferase (ALT) 41
Decreased appetite 40

Outcome Breakdown

Ongoing
189 (39.2%)
Outcome Unknown
154 (32.0%)
Recovered/Normal
77 (16.0%)
Euthanized
43 (8.9%)
Died
18 (3.7%)
Recovered with Sequela
1 (0.2%)

Prescription Diet Adverse Event Insights

482 reports name Prescription Diet; 61 recorded a death outcome (12.7% of reported events, not a population-level mortality rate). Active ingredient: Prescription Diet. Administration routes: Unknown, Oral.

By species: Cat (265 reports), Dog (216 reports), Fallow (1 reports). By breed: Domestic Shorthair (175), Domestic Longhair (34), Retriever - Labrador (21).

Leading clinical signs: Weight loss (100), Ketosis (96), Diarrhoea (94), Vomiting (83). Outcome, 482 coded reports: Ongoing leads at 39.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.