Drug profile

The FDA adverse-event record for Supplement

141 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Supplement. See the species affected, top reactions, and outcomes below.

141
adverse-event reports
12.8%
death-coded share
Dog
most-reported species
22
Vomiting - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
141
Total Reports
18
Deaths Reported
12.8%
Death Rate

Active Ingredients

Supplement

Administration Routes

UnknownOral

Species Affected

Dog 112
Cat 20
Human 7
Cattle 2

Most Affected Breeds

Retriever - Labrador 12
Domestic Shorthair 11
Spitz - German Pomeranian 9
Spaniel - King Charles Cavalier 7
Retriever - Golden 7
Unknown 7
Pit Bull 7
Pug 6
Shepherd Dog - German 5
Collie - Border 5

Most Reported Reactions

Vomiting 22
Behavioural disorder NOS 20
Death by euthanasia 16
Diarrhoea 16
Lethargy (see also Central nervous system depression in Neurological) 13
Other abnormal test result NOS 11
Vocalisation 11
Lethargy (see also Central nervous system depression in 'Neurological') 10
Anorexia 10
Weight loss 10
Polydipsia 10
Seizure NOS 10

Outcome Breakdown

Outcome Unknown
51 (35.9%)
Ongoing
37 (26.1%)
Recovered/Normal
35 (24.6%)
Euthanized
16 (11.3%)
Died
3 (2.1%)

Supplement Adverse Event Insights

141 reports name Supplement; 18 recorded a death outcome (12.8% of reported events, not a population-level mortality rate). Active ingredient: Supplement. Administration routes: Unknown, Oral.

By species: Dog (112 reports), Cat (20 reports), Human (7 reports). By breed: Retriever - Labrador (12), Domestic Shorthair (11), Spitz - German Pomeranian (9).

Leading clinical signs: Vomiting (22), Behavioural disorder NOS (20), Death by euthanasia (16), Diarrhoea (16). Outcome, 142 coded reports: Outcome Unknown leads at 35.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.