Drug profile

The FDA adverse-event record for Polysulfated Glycosaminoglycan

5,558 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Polysulfated Glycosaminoglycan. See the species affected, top reactions, and outcomes below.

5,558
adverse-event reports
7.7%
death-coded share
Dog
most-reported species
1,033
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
5,558
Total Reports
430
Deaths Reported
7.7%
Death Rate

Active Ingredients

Polysulfated Glycosaminoglycan

Administration Routes

UnknownSubcutaneousIntramuscularParenteralIntravenousIntra-ArticularOralTopicalOphthalmicIntradermal

Species Affected

Dog 3,834
Unknown 1,000
Horse 372
Cat 303
Human 27
Other Birds 7
Other 6
Rabbit 4
Duck 1
Starling 1

Most Affected Breeds

Unknown 1,136
Retriever - Labrador 704
Dog (unknown) 319
Shepherd Dog - German 279
Retriever - Golden 224
Domestic Shorthair 168
Dog (other) 99
Boxer (German Boxer) 94
Horse (unknown) 82
Chihuahua 80

Most Reported Reactions

Vomiting 1,033
Diarrhoea 743
Product Defect, General 653
Lack of efficacy - NOS 563
Lethargy (see also Central nervous system depression in 'Neurological') 530
Not eating 366
Color, Abnormal 267
Death by euthanasia 265
Other abnormal test result NOS 237
Elevated alanine aminotransferase (ALT) 234
Anorexia 229
Weight loss 223

Outcome Breakdown

Outcome Unknown
1,740 (38.2%)
Recovered/Normal
1,508 (33.1%)
Ongoing
848 (18.6%)
Euthanized
262 (5.7%)
Died
168 (3.7%)
Recovered with Sequela
33 (0.7%)

Polysulfated Glycosaminoglycan Adverse Event Insights

5,558 reports name Polysulfated Glycosaminoglycan; 430 recorded a death outcome (7.7% of reported events, not a population-level mortality rate). Active ingredient: Polysulfated Glycosaminoglycan. Administration routes: Unknown, Subcutaneous, Intramuscular, Parenteral.

By species: Dog (3,834 reports), Unknown (1,000 reports), Horse (372 reports). By breed: Unknown (1,136), Retriever - Labrador (704), Dog (unknown) (319).

Leading clinical signs: Vomiting (1,033), Diarrhoea (743), Product Defect, General (653), Lack of efficacy - NOS (563). Outcome, 4,559 coded reports: Outcome Unknown leads at 38.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.