Drug profile

The FDA adverse-event record for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane

61 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane. Species, reactions, and outcomes follow.

#1004 of 2,679
by report volume (all drugs)
61
adverse-event reports
8.2%
death-coded share
Dog
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane ranks #1004 of 2679 by total reports (61) and #631 of 1130 by death-coded share (8.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1004
This drug, reports of 2679
#631
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane has 61 reports now versus 60 in that prior snapshot: 1 more (1.7%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane changes

Signature read: report volume at 61 is the most distinctive stamp on Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
61
Total Reports
5
Deaths Reported
8.2%
Death-coded share of reports

Active Ingredients

Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane

Administration Routes

OralUnknownTransdermal

Species Affected

Dog 60
Cat 1

Most Affected Breeds

Retriever - Labrador 17
Shepherd Dog - German 4
Pit Bull 3
Collie - Border 2
Spitz - German Pomeranian 2
Corgi (unspecified) 2
Retriever - Golden 2
Mountain Dog - Bernese 2
Spaniel - King Charles Cavalier 2
Brittany 1

Most Reported Reactions

Diarrhoea 15
Vomiting 10
Other abnormal test result NOS 9
Lethargy (see also Central nervous system depression in 'Neurological') 8
Anorexia 6
Lack of efficacy - NOS 5
Elevated alanine aminotransferase (ALT) 5
Weight loss 5
Abdominal pain 5
Seizure NOS 4
Behavioural disorder NOS 4
Inappetence 4

Outcome Breakdown

Ongoing
22 (36.1%)
Outcome Unknown
20 (32.8%)
Recovered/Normal
14 (23.0%)
Died
3 (4.9%)
Euthanized
2 (3.3%)

Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (61 here).

Clostr Perf*2/Clos Others*6 Kb 61 Distemper 61 Feline Leukemia 61 Firocoxib 57 Mg 61

Similar death-coded share

Nearest other drugs by death-coded share (8.2% here), distinct from the volume row.

Diphenhydramine 8.2% Polysulfated Glycosaminoglycan 8.2% Dhpp 8.2% Pilocarpine 8.2%

What to do with this drug

  • Compare Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate + Methylsulfonylmethane (#1004 of 2,679 by report volume); death-coded 8.2%. PlainBreed drug row · report volume stamp 61 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →