Drug profile

The FDA adverse-event record for Dhpp

68 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dhpp. See the species affected, top reactions, and outcomes below.

68
adverse-event reports
7.4%
death-coded share
Dog
most-reported species
18
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
68
Total Reports
5
Deaths Reported
7.4%
Death Rate

Active Ingredients

Dhpp

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 68

Most Affected Breeds

Retriever - Golden 5
Maltese 4
Shepherd Dog - Australian 4
Poodle - Miniature 3
Shih Tzu 3
Siberian Husky 3
Chihuahua 3
Rottweiler 3
Crossbred Canine/dog 2
Poodle (unspecified) 2

Most Reported Reactions

Vomiting 18
Lethargy (see also Central nervous system depression in 'Neurological') 11
Facial swelling (see also 'Skin') 9
Anaphylaxis 9
Lethargy (see also Central nervous system depression in Neurological) 8
Seizure NOS 7
Diarrhoea 7
Pale mucous membrane 6
Facial swelling (see also Skin) 6
Erythema (for urticaria see Immune SOC) 5
Hives (see also 'Skin') 5
Vocalisation 5

Outcome Breakdown

Recovered/Normal
30 (44.1%)
Ongoing
30 (44.1%)
Outcome Unknown
3 (4.4%)
Euthanized
3 (4.4%)
Died
2 (2.9%)

Dhpp Adverse Event Insights

68 reports name Dhpp; 5 recorded a death outcome (7.4% of reported events, not a population-level mortality rate). Active ingredient: Dhpp. Administration routes: Subcutaneous, Unknown.

By species: Dog (68 reports). By breed: Retriever - Golden (5), Maltese (4), Shepherd Dog - Australian (4).

Leading clinical signs: Vomiting (18), Lethargy (see also Central nervous system depression in 'Neurological') (11), Facial swelling (see also 'Skin') (9), Anaphylaxis (9). Outcome, 68 coded reports: Recovered/Normal leads at 44.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.