Drug profile

The FDA adverse-event record for Dhpp

73 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dhpp. Species, reactions, and outcomes follow.

#914 of 2,679
by report volume (all drugs)
73
adverse-event reports
8.2%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dhpp ranks #914 of 2679 by total reports (73) and #628 of 1130 by death-coded share (8.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#914
This drug, reports of 2679
#628
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dhpp has 73 reports now versus 72 in that prior snapshot: 1 more (1.4%).

Report change
+1
Death-coded reports
+1
Death-coded share
+1.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dhpp changes

Signature read: report volume at 73 is the most distinctive stamp on Dhpp's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
73
Total Reports
6
Deaths Reported
8.2%
Death-coded share of reports

Active Ingredients

Dhpp

Administration Routes

SubcutaneousUnknown

Species Affected

Dog 73

Most Affected Breeds

Retriever - Golden 6
Maltese 4
Shepherd Dog - Australian 4
Poodle - Miniature 3
Shih Tzu 3
Siberian Husky 3
Chihuahua 3
Spaniel - King Charles Cavalier 3
Rottweiler 3
Crossbred Canine/dog 2

Most Reported Reactions

Vomiting 19
Lethargy (see also Central nervous system depression in 'Neurological') 11
Lethargy (see also Central nervous system depression in Neurological) 11
Anaphylaxis 10
Facial swelling (see also 'Skin') 9
Seizure NOS 7
Diarrhoea 7
Pale mucous membrane 6
Fever 6
Emesis 6
Facial swelling (see also Skin) 6
Erythema (for urticaria see Immune SOC) 5

Outcome Breakdown

Recovered/Normal
32 (43.8%)
Ongoing
32 (43.8%)
Outcome Unknown
3 (4.1%)
Euthanized
3 (4.1%)
Died
3 (4.1%)

Dhpp Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Dhpp, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dhpp (#914 of 2,679 by report volume); death-coded 8.2%. PlainBreed drug row · report volume stamp 73 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →