Drug profile

The FDA adverse-event record for Da2Ppl Vaccine

86 FDA reports name Da2Ppl Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#843 of 2,679
by report volume (all drugs)
86
adverse-event reports
12.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Da2Ppl Vaccine ranks #843 of 2679 by total reports (86) and #430 of 1130 by death-coded share (12.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#843
This drug, reports of 2679
#430
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Da2Ppl Vaccine has 86 reports now versus 86 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Da2Ppl Vaccine changes

Signature read: death-coded report count at 11 is the most distinctive stamp on Da2Ppl Vaccine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
86
Total Reports
11
Deaths Reported
12.8%
Death-coded share of reports

Active Ingredients

Da2Ppl Vaccine

Administration Routes

UnknownSubcutaneousParenteralOral

Species Affected

Dog 86

Most Affected Breeds

Chihuahua 8
Retriever - Labrador 8
Retriever (unspecified) 6
Maltese 4
Schnauzer (unspecified) 4
Shepherd Dog - German 3
Boxer (German Boxer) 3
Beagle 3
Terrier (unspecified) 3
Bulldog 3

Most Reported Reactions

Emesis 28
Vomiting 24
Lethargy (see also Central nervous system depression in 'Neurological') 18
Diarrhoea 9
Behavioural disorder NOS 8
Abnormal radiograph finding 7
Lack of efficacy - NOS 7
Death 6
Anorexia 6
Not eating 5
Dehydration 5
Death by euthanasia 5

Outcome Breakdown

Recovered/Normal
49 (57.0%)
Recovered with Sequela
11 (12.8%)
Outcome Unknown
9 (10.5%)
Died
7 (8.1%)
Ongoing
6 (7.0%)
Euthanized
4 (4.7%)

Da2Ppl Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Da2Ppl Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Da2Ppl Vaccine (#843 of 2,679 by report volume); death-coded 12.8%. PlainBreed drug row · death-coded report count stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →