Drug profile

The FDA adverse-event record for Febantel, Pyrantel, Praziquantel

84 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Febantel, Pyrantel, Praziquantel. See the species affected, top reactions, and outcomes below.

84
adverse-event reports
1.2%
death-coded share
Dog
most-reported species
24
Lack of efficacy (endoparasite) - hookworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
84
Total Reports
1
Deaths Reported
1.2%
Death Rate

Active Ingredients

Febantel, Pyrantel, Praziquantel

Administration Routes

OralUnknown

Species Affected

Dog 84

Most Affected Breeds

Retriever - Golden 11
Greyhound 9
Retriever - Labrador 8
Crossbred Canine/dog 6
Beagle 5
Shepherd Dog - German 4
Pit Bull 3
Collie - Border 3
Chihuahua 3
Terrier - Yorkshire 3

Most Reported Reactions

Lack of efficacy (endoparasite) - hookworm 24
Lack of efficacy (endoparasite) - tapeworm 20
Vomiting 19
Diarrhoea 9
Underdose 7
Emesis (multiple) 6
Lack of efficacy (endoparasite) - roundworm NOS 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Overdose 4
Bloody diarrhoea 4
Lack of efficacy (endoparasite) - heartworm 3
Lack of efficacy (endoparasite) - whipworm 3

Outcome Breakdown

Outcome Unknown
49 (58.3%)
Recovered/Normal
17 (20.2%)
Ongoing
16 (19.0%)
Recovered with Sequela
1 (1.2%)
Died
1 (1.2%)

Febantel, Pyrantel, Praziquantel Adverse Event Insights

84 reports name Febantel, Pyrantel, Praziquantel; 1 recorded a death outcome (1.2% of reported events, not a population-level mortality rate). Active ingredient: Febantel, Pyrantel, Praziquantel. Administration routes: Oral, Unknown.

By species: Dog (84 reports). By breed: Retriever - Golden (11), Greyhound (9), Retriever - Labrador (8).

Leading clinical signs: Lack of efficacy (endoparasite) - hookworm (24), Lack of efficacy (endoparasite) - tapeworm (20), Vomiting (19), Diarrhoea (9). Outcome, 84 coded reports: Outcome Unknown leads at 58.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.