Drug profile

The FDA adverse-event record for Methocarbamol

624 FDA reports name Methocarbamol, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#260 of 2,679
by report volume (all drugs)
624
adverse-event reports
23.2%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Methocarbamol ranks #260 of 2679 by total reports (624) and #196 of 1130 by death-coded share (23.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#260
This drug, reports of 2679
#196
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Methocarbamol has 624 reports now versus 611 in that prior snapshot: 13 more (2.1%).

Report change
+13
Death-coded reports
+5
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Methocarbamol changes

Signature read: death-coded report count at 145 is the most distinctive stamp on Methocarbamol's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
624
Total Reports
145
Deaths Reported
23.2%
Death-coded share of reports

Active Ingredients

Methocarbamol

Administration Routes

UnknownOralIntravenousSubcutaneousRectal

Species Affected

Dog 578
Cat 39
Horse 5
Unknown 1
Human 1

Most Affected Breeds

Retriever - Labrador 62
Domestic Shorthair 29
Chihuahua 27
Dachshund (unspecified) 25
Beagle 23
Crossbred Canine/dog 22
Bulldog - French 20
Shepherd Dog - German 18
Shih Tzu 18
Terrier - Bull - American Pit 16

Most Reported Reactions

Vomiting 127
Death by euthanasia 96
Seizure NOS 87
Ataxia 82
Lethargy (see also Central nervous system depression in 'Neurological') 81
Diarrhoea 66
Anorexia 62
Other abnormal test result NOS 54
Abnormal radiograph finding 50
Pain NOS 49
Elevated alanine aminotransferase (ALT) 49
Tremor 49

Outcome Breakdown

Ongoing
251 (40.3%)
Outcome Unknown
118 (18.9%)
Recovered/Normal
103 (16.5%)
Euthanized
96 (15.4%)
Died
49 (7.9%)
Recovered with Sequela
6 (1.0%)

Methocarbamol: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Methocarbamol, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Methocarbamol (#260 of 2,679 by report volume); death-coded 23.2%. PlainBreed drug row · death-coded report count stamp 145 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →