Drug profile

The FDA adverse-event record for Eprinomectin + Praziquantel

620 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Eprinomectin + Praziquantel. See the species affected, top reactions, and outcomes below.

620
adverse-event reports
4.7%
death-coded share
Cat
most-reported species
98
Hypersalivation - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
620
Total Reports
29
Deaths Reported
4.7%
Death Rate

Active Ingredients

EprinomectinPraziquantel

Administration Routes

TopicalOtherUnknownOralTransdermalOphthalmicRespiratory (Inhalation)

Species Affected

Cat 578
Unknown 34
Human 8

Most Affected Breeds

Domestic Shorthair 356
Cat (unknown) 99
Unknown 42
Domestic Mediumhair 39
Domestic Longhair 38
Siamese 11
Maine Coon 7
Ragdoll 4
Persian 3
Russian 3

Most Reported Reactions

Hypersalivation 98
Vomiting 85
Lethargy (see also Central nervous system depression in 'Neurological') 83
Foaming at the mouth 60
Lack of efficacy (endoparasite) - tapeworm 57
Drooling 45
Incorrect route of drug administration 40
Dilated pupils 34
Lack of efficacy (endoparasite) - roundworm NOS 34
Application site hair loss 29
Ataxia 27
Not eating 24

Outcome Breakdown

Outcome Unknown
374 (63.6%)
Recovered/Normal
165 (28.1%)
Ongoing
20 (3.4%)
Died
16 (2.7%)
Euthanized
13 (2.2%)

Eprinomectin + Praziquantel Adverse Event Insights

620 reports name Eprinomectin + Praziquantel; 29 recorded a death outcome (4.7% of reported events, not a population-level mortality rate). Active ingredients: Eprinomectin, Praziquantel. Administration routes: Topical, Other, Unknown, Oral.

By species: Cat (578 reports), Unknown (34 reports), Human (8 reports). By breed: Domestic Shorthair (356), Cat (unknown) (99), Unknown (42).

Leading clinical signs: Hypersalivation (98), Vomiting (85), Lethargy (see also Central nervous system depression in 'Neurological') (83), Foaming at the mouth (60). Outcome, 588 coded reports: Outcome Unknown leads at 63.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.