Drug profile

The FDA adverse-event record for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str

623 FDA reports name Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#261 of 2,679
by report volume (all drugs)
623
adverse-event reports
10.1%
death-coded share
Dog
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str ranks #261 of 2679 by total reports (623) and #542 of 1130 by death-coded share (10.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#261
This drug, reports of 2679
#542
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str has 623 reports now versus 548 in that prior snapshot: 75 more (13.7%).

Report change
+75
Death-coded reports
+4
Death-coded share
−0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str changes

Signature read: 623 reports place Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str in the upper third of FDA AER volume (#261 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
623
Total Reports
63
Deaths Reported
10.1%
Death-coded share of reports

Active Ingredients

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str

Administration Routes

SubcutaneousUnknownOral

Species Affected

Dog 623

Most Affected Breeds

Retriever - Labrador 45
Retriever - Golden 43
Chihuahua 40
Crossbred Canine/dog 34
Terrier - Bull - American Pit 32
Dachshund (unspecified) 27
Bulldog - French 24
Dachshund - Miniature 23
Terrier - Yorkshire 18
Schnauzer - Miniature 18

Most Reported Reactions

Vomiting 208
Lethargy (see also Central nervous system depression in Neurological) 149
Facial swelling (see also Skin) 113
Anaphylaxis 86
Diarrhoea 71
Pale mucous membrane 69
Emesis (multiple) 67
Hives (see also Skin) 62
Not eating 61
Seizure NOS 43
Fever 41
Death 37

Outcome Breakdown

Ongoing
326 (52.3%)
Recovered/Normal
192 (30.8%)
Outcome Unknown
42 (6.7%)
Died
40 (6.4%)
Euthanized
23 (3.7%)

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (10.1% here), distinct from the volume row.

Anesthetic (Unknown) 10.1% Corona Vaccine 10.1% Recombitek C4 - 13D1.R1 10.1% Pyrantel 10.2%

What to do with this drug

  • Compare Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str (#261 of 2,679 by report volume); death-coded 10.1%. PlainBreed drug row · report volume stamp 623 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →