Drug profile

The FDA adverse-event record for Marbofloxacin

1,039 FDA reports name Marbofloxacin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#174 of 2,679
by report volume (all drugs)
1,039
adverse-event reports
14.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Marbofloxacin ranks #174 of 2679 by total reports (1,039) and #400 of 1130 by death-coded share (14.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#174
This drug, reports of 2679
#400
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Marbofloxacin has 1,039 reports now versus 1,024 in that prior snapshot: 15 more (1.5%).

Report change
+15
Death-coded reports
+2
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Marbofloxacin changes

Signature read: death-coded report count at 146 is the most distinctive stamp on Marbofloxacin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,039
Total Reports
146
Deaths Reported
14.1%
Death-coded share of reports

Active Ingredients

Marbofloxacin

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 711
Cat 308
Unknown 19
Human 1

Most Affected Breeds

Domestic Shorthair 149
Retriever - Labrador 72
Domestic (unspecified) 45
Crossbred Canine/dog 43
Shih Tzu 33
Dog (unknown) 32
Chihuahua 30
Shepherd Dog - German 23
Retriever - Golden 21
Pug 21

Most Reported Reactions

Vomiting 174
Anorexia 135
Lethargy (see also Central nervous system depression in 'Neurological') 135
Other abnormal test result NOS 101
Death by euthanasia 87
Lack of efficacy - NOS 85
Lack of efficacy (bacteria) - NOS 76
Weight loss 75
Anaemia NOS 67
Diarrhoea 67
Ataxia 66
Decreased appetite 63

Outcome Breakdown

Ongoing
403 (44.4%)
Outcome Unknown
204 (22.5%)
Recovered/Normal
146 (16.1%)
Euthanized
77 (8.5%)
Died
69 (7.6%)
Recovered with Sequela
9 (1.0%)

Marbofloxacin: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Marbofloxacin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (14.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Marbofloxacin (#174 of 2,679 by report volume); death-coded 14.1%. PlainBreed drug row · death-coded report count stamp 146 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →