Drug profile

The FDA adverse-event record for Praziquantel;Moxidectin

189 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Praziquantel;Moxidectin. See the species affected, top reactions, and outcomes below.

189
adverse-event reports
13.8%
death-coded share
Horse
most-reported species
30
Colic - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
189
Total Reports
26
Deaths Reported
13.8%
Death Rate

Active Ingredients

Praziquantel;Moxidectin

Administration Routes

OralUnknownOphthalmicIntramuscular

Species Affected

Horse 142
Unknown 26
Dog 12
Human 5
Other Equids 3
Donkey 1

Most Affected Breeds

Quarter Horse 50
Unknown 32
Horse (unknown) 15
Thoroughbred 14
Warmblood (unspecified) 8
Paint 8
Miniature 6
Friesian 4
Arab 4
Morgan 3

Most Reported Reactions

Colic 30
Diarrhoea 20
Fever 15
Death by euthanasia 14
Ataxia 14
Death 11
Lethargy (see also Central nervous system depression in 'Neurological') 11
Anorexia 10
Underfilling, Container 9
Seizure NOS 8
Lack of efficacy (endoparasite) - strongylids 8
Lack of efficacy - NOS 7

Outcome Breakdown

Recovered/Normal
56 (33.9%)
Outcome Unknown
43 (26.1%)
Ongoing
39 (23.6%)
Euthanized
13 (7.9%)
Died
13 (7.9%)
Recovered with Sequela
1 (0.6%)

Praziquantel;Moxidectin Adverse Event Insights

189 reports name Praziquantel;Moxidectin; 26 recorded a death outcome (13.8% of reported events, not a population-level mortality rate). Active ingredient: Praziquantel;Moxidectin. Administration routes: Oral, Unknown, Ophthalmic, Intramuscular.

By species: Horse (142 reports), Unknown (26 reports), Dog (12 reports). By breed: Quarter Horse (50), Unknown (32), Horse (unknown) (15).

Leading clinical signs: Colic (30), Diarrhoea (20), Fever (15), Death by euthanasia (14). Outcome, 165 coded reports: Recovered/Normal leads at 33.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.