Drug profile

The FDA adverse-event record for Glycopyrrolate

159 FDA reports name Glycopyrrolate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#605 of 2,679
by report volume (all drugs)
159
adverse-event reports
25.2%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glycopyrrolate ranks #605 of 2679 by total reports (159) and #168 of 1130 by death-coded share (25.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#605
This drug, reports of 2679
#168
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glycopyrrolate has 159 reports now versus 151 in that prior snapshot: 8 more (5.3%).

Report change
+8
Death-coded reports
+0
Death-coded share
−1.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Glycopyrrolate changes

Signature read: death-coded report count at 40 is the most distinctive stamp on Glycopyrrolate's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
159
Total Reports
40
Deaths Reported
25.2%
Death-coded share of reports

Active Ingredients

Glycopyrrolate

Administration Routes

UnknownSubcutaneousIntramuscularParenteralIntravenousOther

Species Affected

Dog 92
Cat 63
Guinea Pig 3
Rabbit 1

Most Affected Breeds

Domestic Shorthair 35
Retriever - Labrador 17
Domestic Mediumhair 8
Domestic Longhair 7
Crossbred Canine/dog 5
Maltese 4
Terrier (unspecified) 4
Dog (unknown) 4
Shepherd Dog - German 4
Lhasa Apso 3

Most Reported Reactions

Death 31
Cardiac arrest 21
Vomiting 20
Other abnormal test result NOS 16
Bradycardia 15
Not eating 14
Lethargy (see also Central nervous system depression in 'Neurological') 13
Behavioural disorder NOS 12
Fever 11
Anorexia 10
Inappetence 10
Abnormal ultrasound finding 9

Outcome Breakdown

Recovered/Normal
63 (39.6%)
Ongoing
34 (21.4%)
Died
32 (20.1%)
Outcome Unknown
21 (13.2%)
Euthanized
8 (5.0%)
Recovered with Sequela
1 (0.6%)

Glycopyrrolate: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Glycopyrrolate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glycopyrrolate (#605 of 2,679 by report volume); death-coded 25.2%. PlainBreed drug row · death-coded report count stamp 40 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →