Drug profile

The FDA adverse-event record for Vitamin B Complex

111 FDA reports name Vitamin B Complex, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#742 of 2,679
by report volume (all drugs)
111
adverse-event reports
25.2%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Vitamin B Complex ranks #740 of 2679 by total reports (111) and #166 of 1130 by death-coded share (25.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#740
This drug, reports of 2679
#166
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vitamin B Complex has 111 reports now versus 107 in that prior snapshot: 4 more (3.7%).

Report change
+4
Death-coded reports
+1
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vitamin B Complex changes

Signature read: death-coded report count at 28 is the most distinctive stamp on Vitamin B Complex's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
111
Total Reports
28
Deaths Reported
25.2%
Death-coded share of reports

Active Ingredients

Vitamin B Complex

Administration Routes

UnknownOralSubcutaneousParenteralIntravenousIntramuscular

Species Affected

Dog 60
Cat 38
Cattle 6
Human 5
Horse 2

Most Affected Breeds

Domestic Shorthair 24
Crossbred Canine/dog 6
Pit Bull 6
Unknown 5
Retriever - Labrador 4
Domestic Longhair 3
Cattle (unknown) 3
Siberian Husky 3
Chihuahua 3
Holstein-Friesian also known as Holstein 2

Most Reported Reactions

Vomiting 21
Death 16
Other abnormal test result NOS 15
Lethargy (see also Central nervous system depression in 'Neurological') 14
Not eating 14
Behavioural disorder NOS 14
Dehydration 14
Diarrhoea 14
Leucocytosis NOS 13
Anorexia 12
Anaemia NOS 12
Weight loss 12

Outcome Breakdown

Outcome Unknown
38 (34.2%)
Recovered/Normal
25 (22.5%)
Ongoing
20 (18.0%)
Died
17 (15.3%)
Euthanized
11 (9.9%)

Vitamin B Complex: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Vitamin B Complex, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vitamin B Complex (#742 of 2,679 by report volume); death-coded 25.2%. PlainBreed drug row · death-coded report count stamp 28 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →