Drug profile

The FDA adverse-event record for Rabacfosadine

335 FDA reports name Rabacfosadine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#389 of 2,679
by report volume (all drugs)
335
adverse-event reports
25.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Rabacfosadine ranks #389 of 2679 by total reports (335) and #169 of 1130 by death-coded share (25.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#389
This drug, reports of 2679
#169
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rabacfosadine has 335 reports now versus 328 in that prior snapshot: 7 more (2.1%).

Report change
+7
Death-coded reports
+2
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rabacfosadine changes

Signature read: death-coded report count at 84 is the most distinctive stamp on Rabacfosadine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
335
Total Reports
84
Deaths Reported
25.1%
Death-coded share of reports

Active Ingredients

Rabacfosadine

Administration Routes

IntravenousUnknownParenteralOtherTopicalSubcutaneousIntramuscular

Species Affected

Dog 315
Unknown 17
Human 3

Most Affected Breeds

Dog (unknown) 66
Retriever - Golden 31
Unknown 22
Retriever - Labrador 21
Pit Bull 11
Shepherd Dog - German 10
Boxer (German Boxer) 9
Crossbred Canine/dog 8
Mountain Dog - Bernese 8
Pug 7

Most Reported Reactions

Diarrhoea 66
Lack of efficacy (neoplasia, no remission) 66
Death by euthanasia 65
Lack of efficacy - NOS 58
Anorexia 38
Decreased appetite 36
Lethargy (see also Central nervous system depression in 'Neurological') 30
Weight loss 25
Death 20
Neutropenia 17
Vomiting 17
Erythema (for urticaria see Immune SOC) 14

Outcome Breakdown

Outcome Unknown
136 (42.4%)
Ongoing
70 (21.8%)
Euthanized
63 (19.6%)
Recovered/Normal
31 (9.7%)
Died
21 (6.5%)

Rabacfosadine: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Rabacfosadine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (25.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rabacfosadine (#389 of 2,679 by report volume); death-coded 25.1%. PlainBreed drug row · death-coded report count stamp 84 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →