Drug profile

The FDA adverse-event record for Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables

114 FDA reports name Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#731 of 2,679
by report volume (all drugs)
114
adverse-event reports
12.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables ranks #730 of 2679 by total reports (114) and #449 of 1130 by death-coded share (12.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#730
This drug, reports of 2679
#449
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables has 114 reports now versus 112 in that prior snapshot: 2 more (1.8%).

Report change
+2
Death-coded reports
+1
Death-coded share
+0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables changes

Signature read: 114 reports place Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables in the upper third of FDA AER volume (#731 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
114
Total Reports
14
Deaths Reported
12.3%
Death-coded share of reports

Active Ingredients

Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables

Administration Routes

UnknownOralIntramuscular

Species Affected

Dog 109
Cat 5

Most Affected Breeds

Retriever - Labrador 15
Shepherd Dog - German 12
Retriever - Golden 11
Dog (other) 6
Unknown 5
Bulldog 4
Domestic Shorthair 4
Chihuahua 4
Dog (unknown) 3
Rottweiler 2

Most Reported Reactions

Vomiting 37
Diarrhoea 23
Not eating 21
Lethargy (see also Central nervous system depression in Neurological) 18
Death by euthanasia 9
Panting 8
Elevated alanine aminotransferase (ALT) 8
Lethargy (see also Central nervous system depression in 'Neurological') 8
Incorrect route of drug administration 8
Lack of efficacy - NOS 7
Bloody diarrhoea 7
Anorexia 6

Outcome Breakdown

Recovered/Normal
47 (41.2%)
Outcome Unknown
41 (36.0%)
Ongoing
12 (10.5%)
Euthanized
8 (7.0%)
Died
6 (5.3%)

Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (114 here).

Similar death-coded share

Nearest other drugs by death-coded share (12.3% here), distinct from the volume row.

What to do with this drug

  • Compare Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Glucosamine, Sodium Chondroitin Sulfate, Avocado/Soybean Unsaponifiables (#731 of 2,679 by report volume); death-coded 12.3%. PlainBreed drug row · report volume stamp 114 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →