Estradiol
113 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
113
Total Reports
18
Deaths Reported
1590.0%
Death Rate
Active Ingredients
Estradiol
Administration Routes
OtherUnknownTopicalSubcutaneousOral
Species Affected
Cattle 62
Dog 30
Unknown 12
Human 5
Cat 2
Other 1
Horse 1
Most Affected Breeds
Holstein-Friesian also known as Holstein 29
Unknown 18
Cattle (unknown) 15
Dog (unknown) 13
Crossbred Bovine/Cattle 8
Mixed (Cattle) 5
Pug 3
Poodle (unspecified) 2
Crossbred Canine/dog 2
Chihuahua 2
Most Reported Reactions
Behavioural disorder NOS 14
Death 12
Accidental exposure 11
Increased sexual interest 10
Mammary gland oedema 10
INEFFECTIVE, WEIGHT INC 8
Vaginal swelling 7
Lack of efficacy - NOS 7
Aggression 6
Alopecia NOS 5
Abnormal oestrus NOS 5
Mammary gland disorder NOS 5
Outcome Breakdown
Outcome Unknown
48 (54.5%)
Died
15 (17.0%)
Recovered/Normal
10 (11.4%)
Ongoing
10 (11.4%)
Euthanized
3 (3.4%)
Recovered with Sequela
2 (2.3%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.