Drug profile

The FDA adverse-event record for Dexdomitor

114 FDA reports name Dexdomitor, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#730 of 2,679
by report volume (all drugs)
114
adverse-event reports
11.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dexdomitor ranks #730 of 2679 by total reports (114) and #483 of 1130 by death-coded share (11.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#730
This drug, reports of 2679
#483
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dexdomitor has 114 reports now versus 113 in that prior snapshot: 1 more (0.9%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dexdomitor changes

Signature read: 114 reports place Dexdomitor in the upper third of FDA AER volume (#730 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
114
Total Reports
13
Deaths Reported
11.4%
Death-coded share of reports

Active Ingredients

Dexdomitor

Administration Routes

UnknownIntramuscularIntravenousParenteralOralSubcutaneous

Species Affected

Dog 97
Cat 16
Rat 1

Most Affected Breeds

Retriever - Labrador 13
Domestic Shorthair 11
Crossbred Canine/dog 8
Pit Bull 5
Retriever (unspecified) 4
Chihuahua 4
Retriever - Golden 4
Spitz - German Pomeranian 3
Dachshund (unspecified) 3
Shepherd Dog - German 3

Most Reported Reactions

Anorexia 21
Lethargy (see also Central nervous system depression in 'Neurological') 17
Vocalisation 17
Sedation 16
Vomiting 16
Not eating 15
Other abnormal test result NOS 13
Hypothermia 13
Lack of efficacy - NOS 11
Diarrhoea 11
Death 8
Inappetence 8

Outcome Breakdown

Recovered/Normal
57 (50.0%)
Outcome Unknown
28 (24.6%)
Ongoing
15 (13.2%)
Died
8 (7.0%)
Euthanized
5 (4.4%)
Recovered with Sequela
1 (0.9%)

Dexdomitor: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Dexdomitor, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (11.4% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dexdomitor (#730 of 2,679 by report volume); death-coded 11.4%. PlainBreed drug row · report volume stamp 114 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →