Drug profile

The FDA adverse-event record for Fluids

696 FDA reports name Fluids, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#239 of 2,679
by report volume (all drugs)
696
adverse-event reports
26.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Fluids ranks #238 of 2679 by total reports (696) and #147 of 1130 by death-coded share (26.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#238
This drug, reports of 2679
#147
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Fluids has 696 reports now versus 675 in that prior snapshot: 21 more (3.1%).

Report change
+21
Death-coded reports
+4
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Fluids changes

Signature read: death-coded report count at 187 is the most distinctive stamp on Fluids's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
696
Total Reports
187
Deaths Reported
26.9%
Death-coded share of reports

Active Ingredients

Fluids

Administration Routes

SubcutaneousIntravenousUnknownOtherParenteralTopicalOral

Species Affected

Dog 426
Cat 265
Horse 3
Other Birds 1
Rabbit 1

Most Affected Breeds

Domestic Shorthair 169
Retriever - Labrador 37
Chihuahua 27
Domestic Longhair 26
Shih Tzu 25
Terrier - Yorkshire 21
Crossbred Canine/dog 21
Shepherd Dog - German 16
Retriever - Golden 15
Domestic Mediumhair 14

Most Reported Reactions

Vomiting 147
Lethargy (see also Central nervous system depression in 'Neurological') 130
Anorexia 124
Death by euthanasia 109
Diarrhoea 91
Not eating 88
Lethargy (see also Central nervous system depression in Neurological) 86
Dehydration 81
Ataxia 80
Death 73
Weight loss 67
Other abnormal test result NOS 63

Outcome Breakdown

Ongoing
201 (28.8%)
Outcome Unknown
172 (24.7%)
Recovered/Normal
130 (18.7%)
Euthanized
108 (15.5%)
Died
79 (11.3%)
Recovered with Sequela
7 (1.0%)

Fluids: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Fluids, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Fluids (#239 of 2,679 by report volume); death-coded 26.9%. PlainBreed drug row · death-coded report count stamp 187 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →