Drug profile

The FDA adverse-event record for Fluids

652 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Fluids. See the species affected, top reactions, and outcomes below.

652
adverse-event reports
26.8%
death-coded share
Dog
most-reported species
139
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
652
Total Reports
175
Deaths Reported
26.8%
Death Rate

Active Ingredients

Fluids

Administration Routes

SubcutaneousIntravenousUnknownOtherParenteralTopical

Species Affected

Dog 395
Cat 252
Horse 3
Other Birds 1
Rabbit 1

Most Affected Breeds

Domestic Shorthair 161
Retriever - Labrador 36
Domestic Longhair 25
Chihuahua 25
Shih Tzu 24
Crossbred Canine/dog 19
Terrier - Yorkshire 18
Shepherd Dog - German 15
Retriever - Golden 13
Siamese 12

Most Reported Reactions

Vomiting 139
Lethargy (see also Central nervous system depression in 'Neurological') 131
Anorexia 115
Death by euthanasia 100
Diarrhoea 85
Ataxia 79
Dehydration 79
Not eating 78
Death 70
Lethargy (see also Central nervous system depression in Neurological) 70
Other abnormal test result NOS 62
Weight loss 59

Outcome Breakdown

Ongoing
180 (27.6%)
Outcome Unknown
170 (26.0%)
Recovered/Normal
121 (18.5%)
Euthanized
99 (15.2%)
Died
76 (11.6%)
Recovered with Sequela
7 (1.1%)

Fluids Adverse Event Insights

652 reports name Fluids; 175 recorded a death outcome (26.8% of reported events, not a population-level mortality rate). Active ingredient: Fluids. Administration routes: Subcutaneous, Intravenous, Unknown, Other.

By species: Dog (395 reports), Cat (252 reports), Horse (3 reports). By breed: Domestic Shorthair (161), Retriever - Labrador (36), Domestic Longhair (25).

Leading clinical signs: Vomiting (139), Lethargy (see also Central nervous system depression in 'Neurological') (131), Anorexia (115), Death by euthanasia (100). Outcome, 653 coded reports: Ongoing leads at 27.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.