Drug profile

The FDA adverse-event record for Cephapirin Benzathine

172 FDA reports name Cephapirin Benzathine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#573 of 2,679
by report volume (all drugs)
172
adverse-event reports
26.7%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Cephapirin Benzathine ranks #572 of 2679 by total reports (172) and #149 of 1130 by death-coded share (26.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#572
This drug, reports of 2679
#149
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cephapirin Benzathine has 172 reports now versus 170 in that prior snapshot: 2 more (1.2%).

Report change
+2
Death-coded reports
+1
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cephapirin Benzathine changes

Signature read: death-coded report count at 46 is the most distinctive stamp on Cephapirin Benzathine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
172
Total Reports
46
Deaths Reported
26.7%
Death-coded share of reports

Active Ingredients

Cephapirin Benzathine

Administration Routes

UnknownIntramammaryOralOphthalmicIntramuscular

Species Affected

Cattle 91
Unknown 74
Goat 3
Horse 2
Human 1
Dog 1

Most Affected Breeds

Unknown 76
Holstein-Friesian also known as Holstein 47
Cattle (other) 26
Cattle (unknown) 10
Jersey 6
Horse (unknown) 2
Brown Swiss 1
Goat (other) 1
Goat (unknown) 1
Pit Bull 1

Most Reported Reactions

Death 42
Tubes, Damaged 24
Residues in milk 22
Product problem 18
Acute mastitis 17
Lack of efficacy (bacteria) - NOS 15
Missing Cap 13
Tubes, Leaking 12
Mammary gland oedema 11
Tubes, Abnormal 10
Uncoded sign 9
Syringe, Abnormal 7

Outcome Breakdown

Died
43 (39.8%)
Outcome Unknown
32 (29.6%)
Recovered/Normal
26 (24.1%)
Ongoing
4 (3.7%)
Euthanized
3 (2.8%)

Cephapirin Benzathine: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Cephapirin Benzathine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (26.7% here), distinct from the volume row.

What to do with this drug

  • Compare Cephapirin Benzathine's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cephapirin Benzathine (#573 of 2,679 by report volume); death-coded 26.7%. PlainBreed drug row · death-coded report count stamp 46 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →