Drug profile

The FDA adverse-event record for Cephapirin Benzathine

169 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cephapirin Benzathine. See the species affected, top reactions, and outcomes below.

169
adverse-event reports
26.0%
death-coded share
Cattle
most-reported species
41
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
169
Total Reports
44
Deaths Reported
26.0%
Death Rate

Active Ingredients

Cephapirin Benzathine

Administration Routes

UnknownIntramammaryOralOphthalmicIntramuscular

Species Affected

Cattle 88
Unknown 74
Goat 3
Horse 2
Human 1
Dog 1

Most Affected Breeds

Unknown 76
Holstein-Friesian also known as Holstein 46
Cattle (other) 25
Cattle (unknown) 9
Jersey 6
Horse (unknown) 2
Brown Swiss 1
Goat (other) 1
Goat (unknown) 1
Pit Bull 1

Most Reported Reactions

Death 41
Tubes, Damaged 24
Residues in milk 22
Product problem 18
Acute mastitis 17
Lack of efficacy (bacteria) - NOS 14
Missing Cap 13
Tubes, Leaking 12
Mammary gland oedema 11
Tubes, Abnormal 10
Uncoded sign 9
Syringe, Abnormal 7

Outcome Breakdown

Died
42 (40.4%)
Outcome Unknown
32 (30.8%)
Recovered/Normal
24 (23.1%)
Ongoing
4 (3.8%)
Euthanized
2 (1.9%)

Cephapirin Benzathine Adverse Event Insights

169 reports name Cephapirin Benzathine; 44 recorded a death outcome (26.0% of reported events, not a population-level mortality rate). Active ingredient: Cephapirin Benzathine. Administration routes: Unknown, Intramammary, Oral, Ophthalmic.

By species: Cattle (88 reports), Unknown (74 reports), Goat (3 reports). By breed: Unknown (76), Holstein-Friesian also known as Holstein (46), Cattle (other) (25).

Leading clinical signs: Death (41), Tubes, Damaged (24), Residues in milk (22), Product problem (18). Outcome, 104 coded reports: Died leads at 40.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.