Drug profile

The FDA adverse-event record for Clomipramine

693 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Clomipramine. See the species affected, top reactions, and outcomes below.

693
adverse-event reports
1.7%
death-coded share
Dog
most-reported species
252
Tablets, Abnormal - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
693
Total Reports
12
Deaths Reported
1.7%
Death Rate

Active Ingredients

Clomipramine

Administration Routes

OralUnknownRespiratory (Inhalation)

Species Affected

Dog 353
Unknown 281
Cat 31
Human 28

Most Affected Breeds

Unknown 310
Crossbred Canine/dog 39
Retriever - Labrador 30
Shih Tzu 15
Domestic Shorthair 13
Shepherd Dog - German 13
Pit Bull 12
Retriever - Golden 12
Terrier - Yorkshire 11
Beagle 11

Most Reported Reactions

Tablets, Abnormal 252
Uncoded sign 209
Lack of efficacy - NOS 81
Vomiting 68
Lethargy (see also Central nervous system depression in 'Neurological') 45
Diarrhoea 40
Behavioural disorder NOS 33
Accidental exposure 32
Elevated alanine aminotransferase (ALT) 30
Elevated serum alkaline phosphatase (SAP) 28
Other abnormal test result NOS 27
Weight loss 26

Outcome Breakdown

Outcome Unknown
126 (38.8%)
Recovered/Normal
93 (28.6%)
Ongoing
88 (27.1%)
Died
8 (2.5%)
Recovered with Sequela
6 (1.8%)
Euthanized
4 (1.2%)

Clomipramine Adverse Event Insights

693 reports name Clomipramine; 12 recorded a death outcome (1.7% of reported events, not a population-level mortality rate). Active ingredient: Clomipramine. Administration routes: Oral, Unknown, Respiratory (Inhalation).

By species: Dog (353 reports), Unknown (281 reports), Cat (31 reports). By breed: Unknown (310), Crossbred Canine/dog (39), Retriever - Labrador (30).

Leading clinical signs: Tablets, Abnormal (252), Uncoded sign (209), Lack of efficacy - NOS (81), Vomiting (68). Outcome, 325 coded reports: Outcome Unknown leads at 38.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.