Drug profile

The FDA adverse-event record for Sodium Chloride

135 FDA reports name Sodium Chloride, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#666 of 2,679
by report volume (all drugs)
135
adverse-event reports
26.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Sodium Chloride ranks #661 of 2679 by total reports (135) and #150 of 1130 by death-coded share (26.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#661
This drug, reports of 2679
#150
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Sodium Chloride has 135 reports now versus 134 in that prior snapshot: 1 more (0.7%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Sodium Chloride changes

Signature read: death-coded report count at 36 is the most distinctive stamp on Sodium Chloride's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
135
Total Reports
36
Deaths Reported
26.7%
Death-coded share of reports

Active Ingredients

Sodium Chloride

Administration Routes

UnknownIntravenousAuricular (Otic)SubcutaneousOtherIntraocularOralIntramuscularEpiduralOphthalmic

Species Affected

Dog 95
Cat 30
Cattle 5
Horse 2
Human 2
Turtle 1

Most Affected Breeds

Domestic Shorthair 16
Retriever - Labrador 12
Pit Bull 5
Terrier - Yorkshire 5
Shepherd Dog - German 4
Spaniel - Cocker American 4
Shih Tzu 4
Dog (unknown) 4
Rottweiler 4
Retriever - Golden 4

Most Reported Reactions

Lack of efficacy - NOS 28
Vomiting 27
Death by euthanasia 21
Lethargy (see also Central nervous system depression in 'Neurological') 19
Anorexia 18
Other abnormal test result NOS 17
Not eating 16
Death 15
Weight loss 15
Behavioural disorder NOS 14
Elevated alanine aminotransferase (ALT) 12
Lethargy (see also Central nervous system depression in Neurological) 12

Outcome Breakdown

Outcome Unknown
37 (26.8%)
Ongoing
33 (23.9%)
Recovered/Normal
32 (23.2%)
Euthanized
20 (14.5%)
Died
16 (11.6%)

Sodium Chloride: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Sodium Chloride, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (26.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Sodium Chloride (#666 of 2,679 by report volume); death-coded 26.7%. PlainBreed drug row · death-coded report count stamp 36 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →