Drug profile

The FDA adverse-event record for Sodium Chloride

129 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sodium Chloride. See the species affected, top reactions, and outcomes below.

129
adverse-event reports
26.4%
death-coded share
Dog
most-reported species
28
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
129
Total Reports
34
Deaths Reported
26.4%
Death Rate

Active Ingredients

Sodium Chloride

Administration Routes

UnknownIntravenousAuricular (Otic)SubcutaneousOtherOralIntramuscularEpiduralOphthalmicIntraocular

Species Affected

Dog 91
Cat 29
Cattle 5
Horse 2
Turtle 1
Human 1

Most Affected Breeds

Domestic Shorthair 15
Retriever - Labrador 12
Pit Bull 5
Terrier - Yorkshire 5
Shepherd Dog - German 4
Spaniel - Cocker American 4
Rottweiler 4
Shih Tzu 4
Dog (unknown) 4
Retriever - Golden 4

Most Reported Reactions

Lack of efficacy - NOS 28
Vomiting 26
Death by euthanasia 20
Lethargy (see also Central nervous system depression in 'Neurological') 19
Anorexia 18
Other abnormal test result NOS 16
Not eating 16
Weight loss 15
Death 14
Behavioural disorder NOS 13
Ataxia 11
Elevated alanine aminotransferase (ALT) 11

Outcome Breakdown

Outcome Unknown
36 (27.3%)
Ongoing
33 (25.0%)
Recovered/Normal
29 (22.0%)
Euthanized
19 (14.4%)
Died
15 (11.4%)

Sodium Chloride Adverse Event Insights

129 reports name Sodium Chloride; 34 recorded a death outcome (26.4% of reported events, not a population-level mortality rate). Active ingredient: Sodium Chloride. Administration routes: Unknown, Intravenous, Auricular (Otic), Subcutaneous.

By species: Dog (91 reports), Cat (29 reports), Cattle (5 reports). By breed: Domestic Shorthair (15), Retriever - Labrador (12), Pit Bull (5).

Leading clinical signs: Lack of efficacy - NOS (28), Vomiting (26), Death by euthanasia (20), Lethargy (see also Central nervous system depression in 'Neurological') (19). Outcome, 132 coded reports: Outcome Unknown leads at 27.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.