Drug profile

The FDA adverse-event record for Flea And Tick Product (Unknown)

249 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Flea And Tick Product (Unknown). See the species affected, top reactions, and outcomes below.

249
adverse-event reports
5.2%
death-coded share
Dog
most-reported species
46
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
249
Total Reports
13
Deaths Reported
5.2%
Death Rate

Active Ingredients

Flea And Tick Product (Unknown)

Administration Routes

UnknownTopicalOralCutaneousOther

Species Affected

Dog 214
Cat 35

Most Affected Breeds

Retriever - Labrador 29
Domestic Shorthair 23
Pit Bull 16
Shepherd Dog - German 12
Chihuahua 11
Crossbred Canine/dog 11
Shih Tzu 10
Dog (unknown) 10
Retriever - Golden 9
Terrier - Yorkshire 6

Most Reported Reactions

Vomiting 46
Lack of efficacy (flea) 29
Lack of efficacy (ectoparasite) - flea 23
Lack of efficacy (endoparasite) - heartworm 18
Lethargy (see also Central nervous system depression in 'Neurological') 17
Diarrhoea 17
Behavioural disorder NOS 15
Not eating 12
Decreased appetite 11
Lack of efficacy (endoparasite) - hookworm 10
Not drinking 10
Other abnormal test result NOS 9

Outcome Breakdown

Outcome Unknown
137 (54.8%)
Recovered/Normal
50 (20.0%)
Ongoing
47 (18.8%)
Died
8 (3.2%)
Euthanized
5 (2.0%)
Recovered with Sequela
3 (1.2%)

Flea And Tick Product (Unknown) Adverse Event Insights

249 reports name Flea And Tick Product (Unknown); 13 recorded a death outcome (5.2% of reported events, not a population-level mortality rate). Active ingredient: Flea And Tick Product (Unknown). Administration routes: Unknown, Topical, Oral, Cutaneous.

By species: Dog (214 reports), Cat (35 reports). By breed: Retriever - Labrador (29), Domestic Shorthair (23), Pit Bull (16).

Leading clinical signs: Vomiting (46), Lack of efficacy (flea) (29), Lack of efficacy (ectoparasite) - flea (23), Lack of efficacy (endoparasite) - heartworm (18). Outcome, 250 coded reports: Outcome Unknown leads at 54.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.