Drug profile

The FDA adverse-event record for Flea And Tick Product (Unknown)

263 FDA reports name Flea And Tick Product (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#459 of 2,679
by report volume (all drugs)
263
adverse-event reports
4.6%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Flea And Tick Product (Unknown) ranks #459 of 2679 by total reports (263) and #809 of 1130 by death-coded share (4.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#459
This drug, reports of 2679
#809
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Flea And Tick Product (Unknown) has 263 reports now versus 263 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Flea And Tick Product (Unknown) changes

Signature read: 263 reports place Flea And Tick Product (Unknown) in the upper third of FDA AER volume (#459 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
263
Total Reports
12
Deaths Reported
4.6%
Death-coded share of reports

Active Ingredients

Flea And Tick Product (Unknown)

Administration Routes

UnknownTopicalOralCutaneousOther

Species Affected

Dog 228
Cat 35

Most Affected Breeds

Retriever - Labrador 31
Domestic Shorthair 23
Pit Bull 17
Shepherd Dog - German 12
Chihuahua 11
Crossbred Canine/dog 11
Shih Tzu 10
Dog (unknown) 10
Retriever - Golden 9
Terrier - Yorkshire 6

Most Reported Reactions

Vomiting 48
Lack of efficacy (flea) 29
Lack of efficacy (ectoparasite) - flea 24
Lack of efficacy (endoparasite) - heartworm 20
Lethargy (see also Central nervous system depression in 'Neurological') 17
Diarrhoea 17
Behavioural disorder NOS 16
Not eating 12
Decreased appetite 11
Other abnormal test result NOS 10
Ataxia 10
Lack of efficacy (endoparasite) - hookworm 10

Outcome Breakdown

Outcome Unknown
145 (55.1%)
Recovered/Normal
52 (19.8%)
Ongoing
51 (19.4%)
Died
7 (2.7%)
Euthanized
5 (1.9%)
Recovered with Sequela
3 (1.1%)

Flea And Tick Product (Unknown): low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Flea And Tick Product (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (263 here).

Similar death-coded share

Nearest other drugs by death-coded share (4.6% here), distinct from the volume row.

What to do with this drug

  • Compare Flea And Tick Product (Unknown)'s report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Flea And Tick Product (Unknown) (#459 of 2,679 by report volume); death-coded 4.6%. PlainBreed drug row · report volume stamp 263 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →