Drug profile

The FDA adverse-event record for Prescription Diet (Unknown)

354 FDA reports name Prescription Diet (Unknown), a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#379 of 2,679
by report volume (all drugs)
354
adverse-event reports
4.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Prescription Diet (Unknown) ranks #379 of 2679 by total reports (354) and #812 of 1130 by death-coded share (4.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#379
This drug, reports of 2679
#812
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Prescription Diet (Unknown) has 354 reports now versus 352 in that prior snapshot: 2 more (0.6%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Prescription Diet (Unknown) changes

Signature read: 354 reports place Prescription Diet (Unknown) in the upper third of FDA AER volume (#379 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
354
Total Reports
16
Deaths Reported
4.5%
Death-coded share of reports

Active Ingredients

Prescription Diet (Unknown)

Administration Routes

OralUnknown

Species Affected

Dog 267
Cat 86
Pig 1

Most Affected Breeds

Domestic Shorthair 48
Crossbred Canine/dog 17
Retriever - Labrador 17
Terrier - Yorkshire 16
Chihuahua 14
Retriever - Golden 13
Shih Tzu 11
Domestic Longhair 11
Maltese 10
Dachshund (unspecified) 10

Most Reported Reactions

Emesis 108
Vomiting 53
Diarrhoea 43
Lack of efficacy - NOS 32
Not eating 30
Lethargy (see also Central nervous system depression in 'Neurological') 29
Weight loss 23
Other abnormal test result NOS 20
Ketosis 18
Decreased appetite 17
Lack of efficacy (ectoparasite) - flea 15
Behavioural disorder NOS 14

Outcome Breakdown

Recovered/Normal
160 (45.2%)
Outcome Unknown
80 (22.6%)
Ongoing
71 (20.1%)
Recovered with Sequela
27 (7.6%)
Died
8 (2.3%)
Euthanized
8 (2.3%)

Prescription Diet (Unknown): low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Prescription Diet (Unknown), both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Prescription Diet (Unknown)'s report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Prescription Diet (Unknown) (#379 of 2,679 by report volume); death-coded 4.5%. PlainBreed drug row · report volume stamp 354 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →