Drug profile

The FDA adverse-event record for Chlorhexidine Shampoo

71 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Chlorhexidine Shampoo. Species, reactions, and outcomes follow.

#928 of 2,679
by report volume (all drugs)
71
adverse-event reports
5.6%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Chlorhexidine Shampoo ranks #928 of 2679 by total reports (71) and #754 of 1130 by death-coded share (5.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#928
This drug, reports of 2679
#754
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Chlorhexidine Shampoo has 71 reports now versus 68 in that prior snapshot: 3 more (4.4%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Chlorhexidine Shampoo changes

Signature read: Chlorhexidine Shampoo's 5.6% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
71
Total Reports
4
Deaths Reported
5.6%
Death-coded share of reports

Active Ingredients

Chlorhexidine Shampoo

Administration Routes

TopicalUnknownOralCutaneousImmersion

Species Affected

Dog 65
Cat 6

Most Affected Breeds

Retriever - Labrador 6
Shih Tzu 6
Domestic Shorthair 5
Schnauzer - Miniature 5
American Pit Bull Terrier 4
Deutsche Dogge, Great Dane 4
Terrier - Yorkshire 2
Pit Bull 2
Spaniel - King Charles Cavalier 2
Shepherd Dog - German 2

Most Reported Reactions

Pruritus 11
Vomiting 9
Emesis 7
Bacterial skin infection NOS 7
Lack of efficacy (ectoparasite) - flea 7
Weight loss 6
Lack of efficacy - NOS 6
Lameness 6
Hair loss NOS 5
Other abnormal test result NOS 5
Skin disorders NOS 5
Lethargy (see also Central nervous system depression in 'Neurological') 5

Outcome Breakdown

Recovered/Normal
25 (35.2%)
Ongoing
20 (28.2%)
Outcome Unknown
20 (28.2%)
Euthanized
3 (4.2%)
Recovered with Sequela
2 (2.8%)
Died
1 (1.4%)

Chlorhexidine Shampoo: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Chlorhexidine Shampoo, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (71 here).

Heartworm Preventative 71 Potassium Citrate 71 Renal Diet 71 Unknown Heartworm Prevention 71

What to do with this drug

  • Compare Chlorhexidine Shampoo's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Chlorhexidine Shampoo (#928 of 2,679 by report volume); death-coded 5.6%. PlainBreed drug row · death-coded share stamp 5.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →