Imidacloprid + Pyriproxyfen
699 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
699
Total Reports
40
Deaths Reported
570.0%
Death Rate
Active Ingredients
ImidaclopridImidacloprid + PyriproxyfenPyriproxyfen
Administration Routes
TopicalUnknownOralOtherIntraocular
Species Affected
Cat 494
Dog 198
Human 5
Rabbit 1
Unknown 1
Most Affected Breeds
Domestic Shorthair 250
Cat (unknown) 89
Domestic Longhair 56
Domestic Mediumhair 39
Pit Bull 20
Terrier - Yorkshire 17
Maine Coon 17
Dog (unknown) 17
Siamese 13
Chihuahua 13
Most Reported Reactions
Lack of efficacy (ectoparasite) - flea 221
Pruritus 214
Behavioural disorder NOS 82
Lethargy (see also Central nervous system depression in 'Neurological') 82
Vomiting 71
Lack of efficacy (endoparasite) - tapeworm 40
Weight loss 37
Application site alopecia 33
Skin lesion NOS 33
Application site pruritus 29
Anorexia 28
Vocalisation 28
Outcome Breakdown
Outcome Unknown
425 (60.9%)
Recovered/Normal
154 (22.1%)
Ongoing
78 (11.2%)
Died
27 (3.9%)
Euthanized
13 (1.9%)
Recovered with Sequela
1 (0.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.