Drug profile

The FDA adverse-event record for Trenbolone Acet/Estradiol Impl

276 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Trenbolone Acet/Estradiol Impl. See the species affected, top reactions, and outcomes below.

276
adverse-event reports
46.4%
death-coded share
Cattle
most-reported species
117
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
276
Total Reports
128
Deaths Reported
46.4%
Death Rate

Active Ingredients

Trenbolone Acet/Estradiol Impl

Administration Routes

SubcutaneousUnknownParenteralOtherIntradermalSubconjunctival

Species Affected

Cattle 181
Unknown 92
Human 3

Most Affected Breeds

Unknown 95
Cattle (other) 91
Crossbred Bovine/Cattle 27
Holstein-Friesian also known as Holstein 17
Aberdeen Angus 15
Mixed (Cattle) 9
Red Angus 7
Cattle (unspecified) 6
Simmental 4
Cattle (unknown) 3

Most Reported Reactions

Death 117
Lack of efficacy - NOS 59
Product problem 34
Color, Abnormal 33
Behavioural disorder NOS 32
Appearance, Abnormal 28
Implant, Abnormal 20
Defect Unknown/Not Specified 16
Uncoded sign 15
Lameness 15
Product Defect, General 14
Unclassifiable adverse event 14

Outcome Breakdown

Died
125 (39.3%)
Outcome Unknown
90 (28.3%)
Ongoing
46 (14.5%)
Recovered/Normal
43 (13.5%)
Euthanized
13 (4.1%)
Recovered with Sequela
1 (0.3%)

Trenbolone Acet/Estradiol Impl Adverse Event Insights

276 reports name Trenbolone Acet/Estradiol Impl; 128 recorded a death outcome (46.4% of reported events, not a population-level mortality rate). Active ingredient: Trenbolone Acet/Estradiol Impl. Administration routes: Subcutaneous, Unknown, Parenteral, Other.

By species: Cattle (181 reports), Unknown (92 reports), Human (3 reports). By breed: Unknown (95), Cattle (other) (91), Crossbred Bovine/Cattle (27).

Leading clinical signs: Death (117), Lack of efficacy - NOS (59), Product problem (34), Color, Abnormal (33). Outcome, 318 coded reports: Died leads at 39.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.