Trenbolone Acet/Estradiol Impl

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276 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
276
Total Reports
128
Deaths Reported
4640.0%
Death Rate

Active Ingredients

Trenbolone Acet/Estradiol Impl

Administration Routes

SubcutaneousUnknownParenteralOtherIntradermalSubconjunctival

Species Affected

Cattle 181
Unknown 92
Human 3

Most Affected Breeds

Unknown 95
Cattle (other) 91
Crossbred Bovine/Cattle 27
Holstein-Friesian also known as Holstein 17
Aberdeen Angus 15
Mixed (Cattle) 9
Red Angus 7
Cattle (unspecified) 6
Simmental 4
Cattle (unknown) 3

Most Reported Reactions

Death 117
Lack of efficacy - NOS 59
Product problem 34
Color, Abnormal 33
Behavioural disorder NOS 32
Appearance, Abnormal 28
Implant, Abnormal 20
Defect Unknown/Not Specified 16
Uncoded sign 15
Lameness 15
Product Defect, General 14
Unclassifiable adverse event 14

Outcome Breakdown

Died
125 (39.3%)
Outcome Unknown
90 (28.3%)
Ongoing
46 (14.5%)
Recovered/Normal
43 (13.5%)
Euthanized
13 (4.1%)
Recovered with Sequela
1 (0.3%)

Data Summary

Metric Value
Total adverse event reports 276
Reports involving death 128
Case-fatality rate (reported events) 4640.0%
Distinct species in reports 3
Distinct breeds in reports 12
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Trenbolone Acet/Estradiol Impl Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 276 adverse event reports referencing Trenbolone Acet/Estradiol Impl, including 128 reports in which the animal died — a 4640.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Trenbolone Acet/Estradiol Impl. Reported administration routes include Subcutaneous, Unknown, Parenteral, Other. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Trenbolone Acet/Estradiol Impl reports are Cattle (181 reports), Unknown (92 reports), Human (3 reports), with Cattle accounting for the largest share. Within those species, Unknown (95), Cattle (other) (91), Crossbred Bovine/Cattle (27) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Trenbolone Acet/Estradiol Impl are Death (117), Lack of efficacy - NOS (59), Product problem (34), Color, Abnormal (33). Of the 318 reports with a coded outcome, Died is the leading category at 39.3%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Trenbolone Acet/Estradiol Impl.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial