Drug profile

The FDA adverse-event record for Trenbolone Acet/Estradiol Impl

279 FDA reports name Trenbolone Acet/Estradiol Impl, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#446 of 2,679
by report volume (all drugs)
279
adverse-event reports
46.6%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Trenbolone Acet/Estradiol Impl ranks #445 of 2679 by total reports (279) and #69 of 1130 by death-coded share (46.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#445
This drug, reports of 2679
#69
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Trenbolone Acet/Estradiol Impl has 279 reports now versus 279 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Trenbolone Acet/Estradiol Impl changes

Signature read: death-coded report count at 130 is the most distinctive stamp on Trenbolone Acet/Estradiol Impl's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
279
Total Reports
130
Deaths Reported
46.6%
Death-coded share of reports

Active Ingredients

Trenbolone Acet/Estradiol Impl

Administration Routes

SubcutaneousUnknownParenteralOtherIntradermalSubconjunctival

Species Affected

Cattle 184
Unknown 92
Human 3

Most Affected Breeds

Unknown 95
Cattle (other) 91
Crossbred Bovine/Cattle 28
Holstein-Friesian also known as Holstein 18
Aberdeen Angus 15
Mixed (Cattle) 10
Red Angus 7
Cattle (unspecified) 6
Simmental 4
Cattle (unknown) 3

Most Reported Reactions

Death 119
Lack of efficacy - NOS 59
Product problem 34
Color, Abnormal 33
Behavioural disorder NOS 33
Appearance, Abnormal 28
Implant, Abnormal 20
Defect Unknown/Not Specified 16
Uncoded sign 15
Lameness 15
Product Defect, General 14
Unclassifiable adverse event 14

Outcome Breakdown

Died
127 (39.4%)
Outcome Unknown
91 (28.3%)
Ongoing
46 (14.3%)
Recovered/Normal
44 (13.7%)
Euthanized
13 (4.0%)
Recovered with Sequela
1 (0.3%)

Trenbolone Acet/Estradiol Impl: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Trenbolone Acet/Estradiol Impl, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (279 here).

Similar death-coded share

Nearest other drugs by death-coded share (46.6% here), distinct from the volume row.

What to do with this drug

  • Compare Trenbolone Acet/Estradiol Impl's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Trenbolone Acet/Estradiol Impl (#446 of 2,679 by report volume); death-coded 46.6%. PlainBreed drug row · death-coded report count stamp 130 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →