Drug profile

The FDA adverse-event record for Amoxicillin Trihydrate

90 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Amoxicillin Trihydrate. See the species affected, top reactions, and outcomes below.

90
adverse-event reports
17.8%
death-coded share
Cat
most-reported species
20
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
90
Total Reports
16
Deaths Reported
17.8%
Death Rate

Active Ingredients

Amoxicillin Trihydrate

Administration Routes

OralUnknownIntramuscularSubcutaneous

Species Affected

Cat 40
Dog 30
Unknown 19
Other 1

Most Affected Breeds

Unknown 20
Domestic Shorthair 14
Domestic (unspecified) 9
Cat (other) 5
Cat (unknown) 4
Dog (unknown) 3
Shepherd Dog - German 3
Retriever - Labrador 2
Terrier - Yorkshire 2
Domestic Longhair 2

Most Reported Reactions

Vomiting 20
Lethargy (see also Central nervous system depression in 'Neurological') 15
Anorexia 14
Diarrhoea 13
Death 8
Lack of efficacy (bacteria) - NOS 7
Death by euthanasia 7
Other abnormal test result NOS 7
Fever 7
Color, Abnormal 6
Elevated alanine aminotransferase (ALT) 6
Seizure NOS 6

Outcome Breakdown

Ongoing
25 (41.0%)
Died
12 (19.7%)
Recovered/Normal
10 (16.4%)
Outcome Unknown
10 (16.4%)
Euthanized
4 (6.6%)

Amoxicillin Trihydrate Adverse Event Insights

90 reports name Amoxicillin Trihydrate; 16 recorded a death outcome (17.8% of reported events, not a population-level mortality rate). Active ingredient: Amoxicillin Trihydrate. Administration routes: Oral, Unknown, Intramuscular, Subcutaneous.

By species: Cat (40 reports), Dog (30 reports), Unknown (19 reports). By breed: Unknown (20), Domestic Shorthair (14), Domestic (unspecified) (9).

Leading clinical signs: Vomiting (20), Lethargy (see also Central nervous system depression in 'Neurological') (15), Anorexia (14), Diarrhoea (13). Outcome, 61 coded reports: Ongoing leads at 41.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.