Drug profile

The FDA adverse-event record for Tramadol Hcl

64 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Tramadol Hcl. See the species affected, top reactions, and outcomes below.

64
adverse-event reports
17.2%
death-coded share
Dog
most-reported species
27
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
64
Total Reports
11
Deaths Reported
17.2%
Death Rate

Active Ingredients

Tramadol Hcl

Administration Routes

OralUnknown

Species Affected

Dog 64

Most Affected Breeds

Retriever - Labrador 10
Terrier - Bull - American Pit 3
Rottweiler 3
Shepherd (unspecified) 3
Collie - Border 3
Terrier - Yorkshire 3
Havanese 3
Terrier - West Highland White 2
Retriever - Golden 2
Shepherd Dog - German 2

Most Reported Reactions

Vomiting 27
Lethargy (see also Central nervous system depression in 'Neurological') 18
Anorexia 11
Elevated alanine aminotransferase (ALT) 10
Other abnormal test result NOS 9
Leucocytosis NOS 8
Diarrhoea 8
Weight loss 8
Anaemia NOS 7
Death by euthanasia 7
Elevated blood urea nitrogen (BUN) 6
Decreased appetite 6

Outcome Breakdown

Ongoing
33 (51.6%)
Recovered/Normal
15 (23.4%)
Euthanized
8 (12.5%)
Outcome Unknown
5 (7.8%)
Died
3 (4.7%)

Tramadol Hcl Adverse Event Insights

64 reports name Tramadol Hcl; 11 recorded a death outcome (17.2% of reported events, not a population-level mortality rate). Active ingredient: Tramadol Hcl. Administration routes: Oral, Unknown.

By species: Dog (64 reports). By breed: Retriever - Labrador (10), Terrier - Bull - American Pit (3), Rottweiler (3).

Leading clinical signs: Vomiting (27), Lethargy (see also Central nervous system depression in 'Neurological') (18), Anorexia (11), Elevated alanine aminotransferase (ALT) (10). Outcome, 64 coded reports: Ongoing leads at 51.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.