Drug profile

The FDA adverse-event record for Glucosamine/Chondroitin

158 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Glucosamine/Chondroitin. See the species affected, top reactions, and outcomes below.

158
adverse-event reports
18.4%
death-coded share
Dog
most-reported species
27
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
158
Total Reports
29
Deaths Reported
18.4%
Death Rate

Active Ingredients

Glucosamine/Chondroitin

Administration Routes

UnknownOral

Species Affected

Dog 145
Cat 13

Most Affected Breeds

Retriever - Labrador 26
Retriever - Golden 18
Domestic Shorthair 11
Shepherd Dog - German 7
Terrier - Bull - American Pit 6
Boxer (German Boxer) 5
Collie - Border 5
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 5
Crossbred Canine/dog 3
Rottweiler 3

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 27
Vomiting 23
Death by euthanasia 21
Anorexia 17
Elevated alanine aminotransferase (ALT) 17
Weight loss 16
Other abnormal test result NOS 15
Panting 14
Diarrhoea 13
Polydipsia 13
Behavioural disorder NOS 11
Not eating 11

Outcome Breakdown

Ongoing
74 (46.8%)
Outcome Unknown
28 (17.7%)
Recovered/Normal
26 (16.5%)
Euthanized
21 (13.3%)
Died
8 (5.1%)
Recovered with Sequela
1 (0.6%)

Glucosamine/Chondroitin Adverse Event Insights

158 reports name Glucosamine/Chondroitin; 29 recorded a death outcome (18.4% of reported events, not a population-level mortality rate). Active ingredient: Glucosamine/Chondroitin. Administration routes: Unknown, Oral.

By species: Dog (145 reports), Cat (13 reports). By breed: Retriever - Labrador (26), Retriever - Golden (18), Domestic Shorthair (11).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (27), Vomiting (23), Death by euthanasia (21), Anorexia (17). Outcome, 158 coded reports: Ongoing leads at 46.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.