Eprinomectin + Esafoxolaner + Praziquantel

2,563 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

2,563

Total Reports

186

Deaths Reported

730.0%

Death Rate

Active Ingredients

EprinomectinEsafoxolanerPraziquantel

Administration Routes

TopicalUnknownOralOphthalmicIntraocularSubcutaneousTransdermalTransplacental

Species Affected

Cat 2,417

Unknown 98

Human 36

Dog 11

Bobcat 1

Most Affected Breeds

Domestic Shorthair 1,487

Cat (unknown) 331

Domestic Longhair 185

Domestic Mediumhair 142

Unknown 136

Siamese 53

Maine Coon 39

Ragdoll 25

Mixed (Cat) 22

Crossbred Feline/cat 20

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 406

Vomiting 310

Application site hair loss 232

Hypersalivation 226

Foaming at the mouth 203

Accidental exposure 189

Drooling 173

Lack of efficacy (ectoparasite) - flea 157

Not eating 153

Ataxia 147

Lack of efficacy (endoparasite) - roundworm NOS 138

Lack of efficacy (endoparasite) - tapeworm 127

Outcome Breakdown

Outcome Unknown

1,428 (57.7%)

Recovered/Normal

677 (27.4%)

Ongoing

178 (7.2%)

Euthanized

94 (3.8%)

Died

93 (3.8%)

Recovered with Sequela

3 (0.1%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.