Drug profile

The FDA adverse-event record for Eprinomectin + Esafoxolaner + Praziquantel

2,563 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Eprinomectin + Esafoxolaner + Praziquantel. See the species affected, top reactions, and outcomes below.

2,563
adverse-event reports
7.3%
death-coded share
Cat
most-reported species
406
Lethargy (see also Central nervous system depression in Neurological) - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,563
Total Reports
186
Deaths Reported
7.3%
Death Rate

Active Ingredients

EprinomectinEsafoxolanerPraziquantel

Administration Routes

TopicalUnknownOralOphthalmicIntraocularSubcutaneousTransdermalTransplacental

Species Affected

Cat 2,417
Unknown 98
Human 36
Dog 11
Bobcat 1

Most Affected Breeds

Domestic Shorthair 1,487
Cat (unknown) 331
Domestic Longhair 185
Domestic Mediumhair 142
Unknown 136
Siamese 53
Maine Coon 39
Ragdoll 25
Mixed (Cat) 22
Crossbred Feline/cat 20

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 406
Vomiting 310
Application site hair loss 232
Hypersalivation 226
Foaming at the mouth 203
Accidental exposure 189
Drooling 173
Lack of efficacy (ectoparasite) - flea 157
Not eating 153
Ataxia 147
Lack of efficacy (endoparasite) - roundworm NOS 138
Lack of efficacy (endoparasite) - tapeworm 127

Outcome Breakdown

Outcome Unknown
1,428 (57.7%)
Recovered/Normal
677 (27.4%)
Ongoing
178 (7.2%)
Euthanized
94 (3.8%)
Died
93 (3.8%)
Recovered with Sequela
3 (0.1%)

Eprinomectin + Esafoxolaner + Praziquantel Adverse Event Insights

2,563 reports name Eprinomectin + Esafoxolaner + Praziquantel; 186 recorded a death outcome (7.3% of reported events, not a population-level mortality rate). Active ingredients: Eprinomectin, Esafoxolaner, Praziquantel. Administration routes: Topical, Unknown, Oral, Ophthalmic.

By species: Cat (2,417 reports), Unknown (98 reports), Human (36 reports). By breed: Domestic Shorthair (1,487), Cat (unknown) (331), Domestic Longhair (185).

Leading clinical signs: Lethargy (see also Central nervous system depression in Neurological) (406), Vomiting (310), Application site hair loss (232), Hypersalivation (226). Outcome, 2,473 coded reports: Outcome Unknown leads at 57.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.