Drug profile

The FDA adverse-event record for Adequan

433 FDA reports name Adequan, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#337 of 2,679
by report volume (all drugs)
433
adverse-event reports
12.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Adequan ranks #337 of 2679 by total reports (433) and #422 of 1130 by death-coded share (12.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#337
This drug, reports of 2679
#422
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Adequan has 433 reports now versus 433 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Adequan changes

Signature read: death-coded report count at 56 is the most distinctive stamp on Adequan's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
433
Total Reports
56
Deaths Reported
12.9%
Death-coded share of reports

Active Ingredients

Adequan

Administration Routes

UnknownSubcutaneousIntramuscularOralIntravenousParenteral

Species Affected

Dog 377
Cat 54
Horse 2

Most Affected Breeds

Retriever - Labrador 72
Shepherd Dog - German 31
Domestic Shorthair 28
Retriever - Golden 25
Terrier - Bull - American Pit 19
Collie - Border 15
Crossbred Canine/dog 14
Dog (unknown) 10
Chihuahua 9
Terrier (unspecified) 9

Most Reported Reactions

Ataxia 57
Lethargy (see also Central nervous system depression in Neurological) 54
Death by euthanasia 42
Polydipsia 40
Polyuria 39
Urinary incontinence 36
Vomiting 35
Lack of efficacy - NOS 31
Diarrhoea 31
Urinary tract infection 31
Limb weakness 31
Not eating 26

Outcome Breakdown

Ongoing
272 (62.8%)
Recovered/Normal
59 (13.6%)
Outcome Unknown
46 (10.6%)
Euthanized
42 (9.7%)
Died
14 (3.2%)

Adequan: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Adequan, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (433 here).

Similar death-coded share

Nearest other drugs by death-coded share (12.9% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Adequan (#337 of 2,679 by report volume); death-coded 12.9%. PlainBreed drug row · death-coded report count stamp 56 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →