Drug profile

The FDA adverse-event record for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St

1,300 FDA reports name Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#152 of 2,679
by report volume (all drugs)
1,300
adverse-event reports
13.0%
death-coded share
Dog
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St ranks #152 of 2679 by total reports (1,300) and #421 of 1130 by death-coded share (13.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#152
This drug, reports of 2679
#421
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St has 1,300 reports now versus 1,300 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St changes

Signature read: death-coded report count at 169 is the most distinctive stamp on Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,300
Total Reports
169
Deaths Reported
13.0%
Death-coded share of reports

Active Ingredients

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St

Administration Routes

SubcutaneousUnknownSubconjunctivalIntramuscular

Species Affected

Dog 1,299
Cat 1

Most Affected Breeds

Retriever - Labrador 109
Terrier - Bull - American Pit 90
Chihuahua 73
Terrier - Yorkshire 68
Shih Tzu 54
Boxer (German Boxer) 54
Pug 47
Retriever - Golden 44
Dachshund (unspecified) 38
Shepherd Dog - German 33

Most Reported Reactions

Vomiting 449
Lethargy (see also Central nervous system depression in 'Neurological') 360
Facial swelling (see also 'Skin') 245
Anaphylactoid reaction 181
Diarrhoea 174
Other abnormal test result NOS 153
Anorexia 134
Pale mucous membrane 130
Hives (see also 'Skin') 121
Emesis 113
Anaphylaxis 110
Urticaria 106

Outcome Breakdown

Ongoing
600 (46.0%)
Recovered/Normal
483 (37.1%)
Died
93 (7.1%)
Euthanized
76 (5.8%)
Outcome Unknown
50 (3.8%)
Recovered with Sequela
1 (0.1%)

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (1,300 here).

Fluralaner Powder For Inj Susp 1,307 Amoxicillin 1,291 Cefpodoxime 1,285 Estriol Tablets 1,320

Similar death-coded share

Nearest other drugs by death-coded share (13.0% here), distinct from the volume row.

Adequan 12.9% Triamcinolone 12.9% Gentamicin, Mometasone Furoate, And Clotrimazole 13.1% Thyroxine 12.9%

What to do with this drug

  • Compare Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St (#152 of 2,679 by report volume); death-coded 13.0%. PlainBreed drug row · death-coded report count stamp 169 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →