Drug profile

The FDA adverse-event record for Benazepril

521 FDA reports name Benazepril, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#297 of 2,679
by report volume (all drugs)
521
adverse-event reports
12.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Benazepril ranks #297 of 2679 by total reports (521) and #425 of 1130 by death-coded share (12.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#297
This drug, reports of 2679
#425
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Benazepril has 521 reports now versus 504 in that prior snapshot: 17 more (3.4%).

Report change
+17
Death-coded reports
+3
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Benazepril changes

Signature read: death-coded report count at 67 is the most distinctive stamp on Benazepril's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
521
Total Reports
67
Deaths Reported
12.9%
Death-coded share of reports

Active Ingredients

Benazepril

Administration Routes

OralUnknownTopicalSubcutaneous

Species Affected

Dog 471
Cat 46
Human 3
Unknown 1

Most Affected Breeds

Retriever - Labrador 36
Terrier - Yorkshire 35
Domestic Shorthair 33
Beagle 31
Chihuahua 25
Shih Tzu 24
Maltese 24
Crossbred Canine/dog 19
Terrier (unspecified) 13
Schnauzer - Miniature 13

Most Reported Reactions

Vomiting 86
Diarrhoea 55
Lethargy (see also Central nervous system depression in 'Neurological') 53
Elevated blood urea nitrogen (BUN) 43
Death by euthanasia 41
Lethargy (see also Central nervous system depression in Neurological) 41
Decreased appetite 40
Anorexia 37
Elevated alanine aminotransferase (ALT) 32
Not eating 28
Weight loss 28
Elevated creatinine 26

Outcome Breakdown

Outcome Unknown
166 (32.0%)
Ongoing
142 (27.4%)
Recovered/Normal
134 (25.8%)
Euthanized
40 (7.7%)
Died
27 (5.2%)
Recovered with Sequela
10 (1.9%)

Benazepril: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Benazepril, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (521 here).

Similar death-coded share

Nearest other drugs by death-coded share (12.9% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Benazepril (#297 of 2,679 by report volume); death-coded 12.9%. PlainBreed drug row · death-coded report count stamp 67 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →