Drug profile

The FDA adverse-event record for Benazepril

483 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Benazepril. See the species affected, top reactions, and outcomes below.

483
adverse-event reports
12.2%
death-coded share
Dog
most-reported species
77
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
483
Total Reports
59
Deaths Reported
12.2%
Death Rate

Active Ingredients

Benazepril

Administration Routes

OralUnknownTopicalSubcutaneous

Species Affected

Dog 438
Cat 41
Human 3
Unknown 1

Most Affected Breeds

Retriever - Labrador 35
Terrier - Yorkshire 34
Domestic Shorthair 28
Beagle 28
Shih Tzu 24
Chihuahua 23
Maltese 20
Schnauzer - Miniature 13
Crossbred Canine/dog 12
Terrier (unspecified) 12

Most Reported Reactions

Vomiting 77
Lethargy (see also Central nervous system depression in 'Neurological') 53
Diarrhoea 52
Elevated blood urea nitrogen (BUN) 42
Death by euthanasia 38
Decreased appetite 38
Lethargy (see also Central nervous system depression in Neurological) 36
Anorexia 34
Elevated alanine aminotransferase (ALT) 31
Not eating 28
Elevated creatinine 26
Seizure NOS 25

Outcome Breakdown

Outcome Unknown
157 (32.6%)
Ongoing
133 (27.7%)
Recovered/Normal
122 (25.4%)
Euthanized
37 (7.7%)
Died
22 (4.6%)
Recovered with Sequela
10 (2.1%)

Benazepril Adverse Event Insights

483 reports name Benazepril; 59 recorded a death outcome (12.2% of reported events, not a population-level mortality rate). Active ingredient: Benazepril. Administration routes: Oral, Unknown, Topical, Subcutaneous.

By species: Dog (438 reports), Cat (41 reports), Human (3 reports). By breed: Retriever - Labrador (35), Terrier - Yorkshire (34), Domestic Shorthair (28).

Leading clinical signs: Vomiting (77), Lethargy (see also Central nervous system depression in 'Neurological') (53), Diarrhoea (52), Elevated blood urea nitrogen (BUN) (42). Outcome, 481 coded reports: Outcome Unknown leads at 32.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.